Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Mol Cell. 2018 Nov 15;72(4):605-607. doi: 10.1016/j.molcel.2018.10.043.
In this issue of Molecular Cell, Weith et al. (2018) demonstrate that p97, together with a SEP adaptor, can catalyze ordered subunit exchange to facilitate the biogenesis of protein phosphatase-1 (PP1) holoenzyme, establishing a novel ubiquitin-independent "segregase" function for this versatile ATPase.
在本期《分子细胞》中，Weith 等人（2018 年）证明 p97 与 SEP 衔接蛋白一起可以催化有序的亚基交换，从而促进蛋白磷酸酶-1（PP1）全酶的生物发生，为这种多功能 ATP 酶建立了一种新的、不依赖泛素的“分离酶”功能。
