Department of Pediatric Endocrinology/Genetics, Shanghai Institute for Pediatric Research, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China
Department of Pediatric Endocrinology/Genetics, Shanghai Institute for Pediatric Research, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.
Biosci Rep. 2018 Dec 14;38(6). doi: 10.1042/BSR20181347. Print 2018 Dec 21.
The association between rs548294 G>A and rs2195450 C>T polymorphisms and migraine risk has been reported in several case-control studies. However, the results of studies are inconsistent. Thus, we conducted a meta-analysis to more precisely estimate the association of the two polymorphisms with migraine risk.
Eligible studies were retrieved and screened from the online databases (EMBASE, PubMed, Web of Science, Wanfang, and Chinese National Knowledge Infrastructure). The pooled odds ratio (OR) with corresponding 95.0% confidence intervals (CIs) was assessed using random- or fixed-effects model.
A total of 1233 cases and 1374 controls from four eligible studies were included. The pooled analysis showed that rs548294 G>A polymorphism was not significantly associated with migraine risk. rs2195450 C>T polymorphism was significantly associated with migraine risk under heterozygous model (CT vs. CC, OR = 1.23, 95%CI = 1.02-1.48, = 0.03). Further subgroup analysis based on ethnicity showed a significant association of rs2195450 C>T polymorphism with migraine risk in Asian population, but not in Caucasian population.
Our results indicates that rs2195450 C>T polymorphism is significantly associated with migraine risk. However, the number of studies included in the meta-analysis was small. Thus, more high quality case-control studies with a large sample size are still required to confirm these findings.
rs548294 G>A 和 rs2195450 C>T 多态性与偏头痛风险的关联已在几项病例对照研究中报道。然而，研究结果并不一致。因此，我们进行了荟萃分析，以更准确地估计这两种多态性与偏头痛风险的关联。
从在线数据库（EMBASE、PubMed、Web of Science、万方和中国国家知识基础设施）中检索和筛选符合条件的研究。使用随机或固定效应模型评估合并的优势比（OR）及其相应的 95.0%置信区间（CI）。
共有四项符合条件的研究纳入了 1233 例病例和 1374 例对照。荟萃分析显示，rs548294 G>A 多态性与偏头痛风险无显著相关性。rs2195450 C>T 多态性在杂合子模型下（CT 与 CC，OR=1.23，95%CI=1.02-1.48， = 0.03）与偏头痛风险显著相关。基于种族的亚组分析进一步表明，rs2195450 C>T 多态性与亚洲人群的偏头痛风险显著相关，但在白人群体中则无显著相关性。
我们的研究结果表明，rs2195450 C>T 多态性与偏头痛风险显著相关。然而，纳入荟萃分析的研究数量较少。因此，仍需要更多高质量的、大样本量的病例对照研究来验证这些发现。
