原发性浆细胞白血病：新型诱导药物时代的自体造血干细胞移植。
Primary plasma cell leukemia: autologous stem cell transplant in an era of novel induction drugs.
机构信息
Division of Hematology, Yale School of Medicine, New Haven, CT, 06511, USA.
Division of Hematologic Malignancies, Mayo Clinic, Rochester, MN, 55905, USA.
出版信息
Bone Marrow Transplant. 2019 Jul;54(7):1089-1093. doi: 10.1038/s41409-018-0392-1. Epub 2018 Nov 16.
Abstract
Primary plasma cell leukemia (pPCL) is a rare and aggressive variant of multiple myeloma (MM) with poor long-term survival after cytotoxic chemotherapy. Many novel drugs have revolutionized the treatment algorithms for MM. The impact of targeted therapy, both pre- and post-autologous stem cell transplant (auto-HCT) remains an area of ongoing interest. In this study, we report outcomes post auto-HCT for pPCL and the impact of maintenance therapy posttransplant with novel agents.
摘要
原发性浆细胞白血病（pPCL）是一种罕见且侵袭性的多发性骨髓瘤（MM）变体，在细胞毒化疗后长期生存预后较差。许多新型药物彻底改变了 MM 的治疗方案。在自体造血干细胞移植（auto-HCT）前后靶向治疗的影响仍然是一个持续关注的领域。在这项研究中，我们报告了 pPCL 患者在 auto-HCT 后的结果，以及新型药物在移植后维持治疗的影响。
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