Unterecker Stefan, Hefner Gudrun, Baumann Pierre, Gründer Gerd, Bergemann Niels, Clement Hans-Willi, Conca Andreas, Deckert Jürgen, Domschke Katharina, Eckermann Gabriel, Egberts Karin, Gerlach Manfred, Greiner Christine, Haen Ekkehard, Havemann-Reinecke Ursula, Helmer Renate, Janssen Ger, Jaquenoud Eveline, Laux Gerd, Messer Thomas, Mössner Rainald, Müller Matthias J, Paulzen Michael, Pfuhlmann Bruno, Riederer Peter, Saria Alois, Schoppek Bernd, Schoretsanitis Georgios, Schwarz Markus, Gracia Margarethe Silva, Stegmann Benedikt, Steimer Werner, Stingl Julia C, Uhr Manfred, Ulrich Sven, Waschgler Roland, Zernig Gerald, Zurek Gabriele, Hiemke Christoph
Klinik für Psychiatrie, Psychosomatik und Psychotherapie, Universitätsklinikum Würzburg, Margarete-Höppel-Platz 1, 97080, Würzburg, Deutschland.
Vitos Klinik Hochtaunus, Waldkrankenhaus Köppern, Emil-Sioli-Weg 1-3, 61381, Friedrichsdorf, Deutschland.
Nervenarzt. 2019 May;90(5):463-471. doi: 10.1007/s00115-018-0643-9.
Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug concentrations in blood serum or plasma to optimize pharmacological therapy. TDM is an instrument with which the high interindividual variability of pharmacokinetics of patients can be identified and therefore enables a personalized pharmacotherapy. In September 2017 the TDM task force of the Working Group for Neuropsychopharmacology and Pharmacopsychiatry (AGNP) published an update of the consensus guidelines on TDM published in 2011. This article summarizes the essential statements for the clinical practice in psychiatry and neurology.
治疗药物监测（TDM）是对血清或血浆中药物浓度进行定量和解释，以优化药物治疗。TDM是一种工具，通过它可以识别患者药代动力学的高个体间变异性，从而实现个性化药物治疗。2017年9月，神经精神药理学和药物精神病学工作组（AGNP）的TDM特别工作组发布了2011年发布的TDM共识指南的更新版。本文总结了精神病学和神经病学临床实践的重要声明。
