Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Clin Pharmacol Ther. 2016 Feb;99(2):148-50. doi: 10.1002/cpt.298. Epub 2015 Dec 9.
The precision medicine initiative is designed to better understand the causes of disease, to develop target therapies, and to identify patients that would benefit from treatment. Prescribing the right dose, which is not always the same to all patients, is needed for a successful outcome. The purpose of this commentary is to discuss the role of dose individualization based on therapeutic drug monitoring as a clinical patient management tool in the application of precision medicine.
精准医学计划旨在更好地了解疾病的原因，开发靶向疗法，并确定受益于治疗的患者。为了取得成功的结果，需要为每个患者确定合适的剂量，而不是对所有患者都使用相同的剂量。本文的目的是讨论基于治疗药物监测的剂量个体化作为精准医学应用中临床患者管理工具的作用。
