质膜H⁺-ATP酶，一种有着悠久历史的简单多肽。
The plasma membrane H -ATPase, a simple polypeptide with a long history.
作者信息
Palmgren Michael, Morsomme Pierre
机构信息
Department of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg C, Denmark.
Louvain Institute of Biomolecular Science and Technology (LIBST), UCLouvain, Louvain-la-Neuve, Belgium.
出版信息
Yeast. 2019 Apr;36(4):201-210. doi: 10.1002/yea.3365. Epub 2018 Dec 10.
Abstract
The plasma membrane H -ATPase of fungi and plants is a single polypeptide of fewer than 1,000 residues that extrudes protons from the cell against a large electric and concentration gradient. The minimalist structure of this nanomachine is in stark contrast to that of the large multi-subunit F F ATPase of mitochondria, which is also a proton pump, but under physiological conditions runs in the reverse direction to act as an ATP synthase. The plasma membrane H -ATPase is a P-type ATPase, defined by having an obligatory phosphorylated reaction cycle intermediate, like cation pumps of animal membranes, and thus, this pump has a completely different mechanism to that of F F ATPases, which operates by rotary catalysis. The work that led to these insights in plasma membrane H -ATPases of fungi and plants has a long history, which is briefly summarized in this review.
摘要
真菌和植物的质膜H⁺-ATP酶是一种由少于1000个残基组成的单一多肽，它能逆着大的电势和浓度梯度将质子排出细胞。这种纳米机器的极简结构与线粒体的大型多亚基F₀F₁-ATP酶形成鲜明对比，后者也是一种质子泵，但在生理条件下运行方向相反，充当ATP合酶。质膜H⁺-ATP酶是一种P型ATP酶，其定义是具有一个必需的磷酸化反应循环中间体，类似于动物膜的阳离子泵，因此，这种泵的机制与通过旋转催化运行的F₀F₁-ATP酶完全不同。在真菌和植物的质膜H⁺-ATP酶方面取得这些见解的研究有着悠久的历史，本综述将对此进行简要总结。
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