Dental Public Health, Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong.
Key Laboratory of Oral Diseases Research of Anhui Province, Stomatologic Hospital & College, Anhui Medical University, Hefei, China.
Oral Dis. 2019 Mar;25(2):617-633. doi: 10.1111/odi.13005. Epub 2018 Dec 18.
This study was to assess the effectiveness of a conventional oral hygiene care programme (COHCP) and an advanced oral hygiene care programme (AOHCP) on prevalence and viable counts of oral opportunistic pathogens among patients undergoing stroke rehabilitation.
A total of 94 patients were randomized to two groups. Subjects were block randomized to either (a) COHCP: manual toothbrushing with oral hygiene instruction (OHI); or (b) AOHCP: powered toothbrushing, mouthrinsing with chlorhexidine and OHI. Prevalence and viable counts of oral opportunistic pathogens including yeasts, aerobic and facultative anaerobic gram-negative bacilli, Staphylococcus aureus, were assessed at baseline, the end of 3 and 6 months.
No significant difference was observed in the prevalence of oral opportunistic pathogens within each group over the clinical trial period. A significant decrease in the viable counts of S. aureus was found over the clinical trial period within AOHCP group (p < 0.05), while the viable counts of yeasts and anaerobic gram-negative bacillus (AGNB) remained stable within each group. Regression analysis failed to detect an association between intervention and the prevalence/viable counts of oral opportunistic pathogens.
Neither oral healthcare programme significantly affects AGNB, yeast or S. aureus over the study period in terms of prevalence and viable counts.
本研究旨在评估常规口腔卫生保健方案（COHCP）和先进口腔卫生保健方案（AOHCP）对接受脑卒中康复治疗的患者口腔机会致病菌的流行率和活菌计数的影响。
共有 94 名患者被随机分为两组。将受试者按区组随机分为（a）COHCP：手动刷牙结合口腔卫生指导（OHI）；或（b）AOHCP：使用动力牙刷、氯己定漱口结合 OHI。在基线、3 个月和 6 个月时，评估口腔机会致病菌（包括酵母菌、需氧和兼性厌氧革兰氏阴性杆菌、金黄色葡萄球菌）的流行率和活菌计数。
在临床试验期间，每个组内口腔机会致病菌的流行率均无显著差异。在 AOHCP 组中，金黄色葡萄球菌的活菌计数在整个临床试验期间呈显著下降趋势（p<0.05），而各组内酵母菌和厌氧革兰氏阴性杆菌（AGNB）的活菌计数保持稳定。回归分析未发现干预与口腔机会致病菌的流行率/活菌计数之间存在关联。
在研究期间，无论采用哪种口腔保健方案，都不会显著影响 AGNB、酵母菌或金黄色葡萄球菌的流行率和活菌计数。
