Aref Nisreen Khaled
Faculty of Medicine, Taif University, Saudi Arabia.
J Gynecol Obstet Hum Reprod. 2019 Jan;48(1):65-68. doi: 10.1016/j.jogoh.2018.11.002. Epub 2018 Nov 14.
To evaluate the efficacy of preoperative vaginal cleansing using povidone-iodine solution 10% on rates of post cesarean section (CS) infectious morbidities (endometritis, febrile morbidity and wound infection).
This prospective randomized trial was conducted among 226 pregnant women scheduled for term elective CS. Patients were equally divided into two groups by simple randomization method. The study group had preoperative vaginal cleansing using povidone-iodine solution 10% for about 1 min, while the control group did not. All cases received the prophylactic antibiotics and the usual abdominal scrub. Adverse post CS infectious morbidities such as endometritis, febrile morbidity and wound infection were observed at the time of hospital discharge and weekly for 6 weeks postpartum.
Both groups were matched regarding the baseline patients' characteristics. Overall, post-CS infectious morbidity was significantly reduced from 20.7% in the control group to 7.5% in the intervention group. Marked significant reduction was seen in the incidence of endometritis (11.8% in the control group versus 2.8% in the intervention group). However, maternal fever and wound infection showed no significant difference between both groups.
Vaginal cleansing with povidone-iodine solution 10% prior to elective CS appears to be effective in reducing rates of post-CS infectious morbidity mainly endometritis.
评估术前使用10%聚维酮碘溶液进行阴道清洁对剖宫产术后感染性疾病（子宫内膜炎、发热性疾病和伤口感染）发生率的影响。
本前瞻性随机试验在226例计划行足月择期剖宫产的孕妇中进行。采用简单随机化方法将患者平均分为两组。研究组术前使用10%聚维酮碘溶液进行阴道清洁约1分钟，而对照组不进行。所有病例均接受预防性抗生素治疗和常规腹部擦洗。在出院时及产后6周每周观察剖宫产术后不良感染性疾病，如子宫内膜炎、发热性疾病和伤口感染。
两组患者的基线特征相匹配。总体而言，剖宫产术后感染性疾病发生率从对照组的20.7%显著降低至干预组的7.5%。子宫内膜炎的发生率显著降低（对照组为11.8%，干预组为2.8%）。然而，两组产妇发热和伤口感染情况无显著差异。
择期剖宫产术前用10%聚维酮碘溶液进行阴道清洁似乎可有效降低剖宫产术后感染性疾病发生率，主要是子宫内膜炎。
