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使用体外膜肺氧合技术救治危重症成人:新南威尔士州的九年经验

Retrieval of critically ill adults using extracorporeal membrane oxygenation: the nine-year experience in New South Wales.

作者信息

Austin D E, Burns B, Lowe D, Cartwright B, Clarke A, Dennis M, D'Souza M, Nathan R, Bannon P G, Gattas D, Connellan M, Forrest P

出版信息

Anaesth Intensive Care. 2018 Nov;46(6):579-588. doi: 10.1177/0310057X1804600608.

DOI:10.1177/0310057X1804600608
PMID:30447667
Abstract

In New South Wales, a coordinated extracorporeal membrane oxygenation (ECMO) retrieval program has been in operation since 2007. This study describes the characteristics and outcomes of patients transported by this service. We performed a retrospective observational study and included patients who were transported on ECMO to either of two adult tertiary referral hospitals in Sydney, New South Wales, between February 28, 2007 and February 29, 2016. One hundred and sixty-four ECMO-facilitated transports occurred, involving 160 patients. Of these, 118 patients (74%) were treated with veno-venous (VV) ECMO and 42 patients (26%) were treated with veno-arterial ECMO. The mean (standard deviation, SD) age was 40.4 (15.0) years. Seventy-seven transports (47%) occurred within metropolitan Sydney, 52 (32%) were from rural or regional areas within NSW, 17 (10%) were interstate transfers and 18 (11%) were international transfers. Transfers were by road (58%), fixed wing aircraft (27%) or helicopter (15%). No deaths occurred during transport. The median (interquartile range) duration of ECMO treatment was 8.9 (5.2-15.3) days. One hundred and nineteen patients (74%) were successfully weaned from ECMO and 109 (68%) survived to hospital discharge or transfer. In patients treated with VV ECMO, age, sequential organ failure assessment score, pre-existing immunosuppressive disease, pre-existing diabetes, renal failure requiring dialysis and failed prone positioning prior to ECMO were independently associated with increased mortality. ECMO-facilitated patient transport is feasible, safe, and results in acceptable short-term outcomes. The NSW ECMO Retrieval Service provides specialised support to patients with severe respiratory and cardiovascular illness, who may otherwise be too unstable to undergo inter-hospital transfer to access advanced cardiovascular and critical care services.

摘要

自2007年以来,新南威尔士州一直在实施一项体外膜肺氧合(ECMO)协同转运计划。本研究描述了通过该服务转运的患者的特征和转归情况。我们进行了一项回顾性观察研究,纳入了2007年2月28日至2016年2月29日期间通过ECMO转运至新南威尔士州悉尼市两家成人三级转诊医院之一的患者。共发生了164次由ECMO辅助的转运,涉及160名患者。其中,118例患者(74%)接受了静脉-静脉(VV)ECMO治疗,42例患者(26%)接受了静脉-动脉ECMO治疗。平均(标准差,SD)年龄为40.4(15.0)岁。77次转运(47%)发生在悉尼大都市地区内,52次(32%)来自新南威尔士州的农村或地区,17次(10%)为州际转运,18次(11%)为国际转运。转运方式为公路(58%)、固定翼飞机(27%)或直升机(15%)。转运过程中无死亡发生。ECMO治疗的中位(四分位间距)持续时间为8.9(5.2 - 15.3)天。119例患者(74%)成功脱离ECMO,109例(68%)存活至出院或转院。在接受VV ECMO治疗的患者中,年龄、序贯器官衰竭评估评分、既往免疫抑制疾病、既往糖尿病、需要透析的肾衰竭以及ECMO前俯卧位失败与死亡率增加独立相关。由ECMO辅助的患者转运是可行、安全的,并且能带来可接受的短期转归。新南威尔士州ECMO转运服务为患有严重呼吸和心血管疾病的患者提供了专门支持,否则这些患者可能因过于不稳定而无法进行院际转运以获得先进的心血管和重症监护服务。

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