Maĭorova I G, Khudoleĭ V V
Eksp Onkol. 1988;10(3):9-14.
Current investigations of modifications of metabolic activation of carcinogens by the environmental chemical factors which are able to induce or inhibit the metabolic activation are reviewed. From the standpoint of ecological oncology the most promising are the following trends: 1) modelling under experimental conditions of integral ecosystems including the complex of living organisms, environmental carcinogens, and factors which modify their biotransformation; 2) study of the imprinting effectors of metabolism modifiers; 3) detection in the environment of modifiers of metabolic activation of carcinogens. The comprehensive oncological-ecological studies of chemicals which influence different pathways of carcinogen metabolism are very important for both primary prevention of cancer and the environmental protection.
本文综述了当前对环境化学因素对致癌物代谢活化的修饰作用的研究，这些环境化学因素能够诱导或抑制代谢活化。从生态肿瘤学的角度来看，最有前景的趋势如下：1）在实验条件下对包括生物体复合体、环境致癌物及其生物转化修饰因子在内的整体生态系统进行建模；2）研究代谢修饰剂的印记效应物；3）在环境中检测致癌物代谢活化的修饰剂。对影响致癌物代谢不同途径的化学物质进行全面的肿瘤学-生态学研究，对癌症的一级预防和环境保护都非常重要。
