Mizgirev I V, Khudoleĭ V V
Eksp Onkol. 1985;7(2):15-9.
The recent data on metabolic activation of carcinogens are presented. Molecular mechanisms of activation, induction methods for systems providing biotransformation of xenobiotics as well as the comparative analysis of these systems (host, cell and cell free) are characterized from the standpoint of their use in short-term tests. The prospects of application of various metabolic activation systems are shown.
本文介绍了致癌物代谢活化的最新数据。从短期试验应用的角度,对活化的分子机制、提供外源化合物生物转化的系统的诱导方法以及这些系统(宿主、细胞和无细胞系统)的比较分析进行了描述。展示了各种代谢活化系统的应用前景。