Kok Beverley, Dong Victor, Karvellas Constantine J
Division of Gastroenterology (Liver Unit), Department of Critical Care Medicine, University of Alberta, 1-40 Zeidler Ledcor Building, Edmonton, Alberta T6G-2X8, Canada.
Division of Gastroenterology (Liver Unit), Department of Critical Care Medicine, University of Alberta, 1-40 Zeidler Ledcor Building, Edmonton, Alberta T6G-2X8, Canada.
Crit Care Clin. 2019 Jan;35(1):117-133. doi: 10.1016/j.ccc.2018.08.002. Epub 2018 Oct 25.
Graft dysfunction of the liver allograft manifests across a spectrum in both timing posttransplantation and clinical presentation. This can range from mild transient abnormalities of liver tests to acute liver failure potentially leading to graft failure. The causes of graft dysfunction can be divided into those resulting in early and late graft dysfunction. Although nonspecific, liver biochemistry abnormalities are still the mainstay investigation used in monitoring for dysfunction. This article provides a summary of the main causes and management strategies for liver graft dysfunction in the early through late posttransplant stages.
肝移植移植物功能障碍在移植后的时间和临床表现方面都呈现出一系列情况。其范围可从肝功能检查的轻度短暂异常到可能导致移植物衰竭的急性肝衰竭。移植物功能障碍的原因可分为导致早期和晚期移植物功能障碍的原因。尽管缺乏特异性，但肝脏生化异常仍是监测功能障碍的主要检查手段。本文总结了肝移植术后早期至晚期移植物功能障碍的主要原因及管理策略。
