体外设备

Extracorporeal Devices.

作者信息

Kandiah Prem A, Subramanian Ram M

机构信息

Division of Neuro Critical Care & co appt. in 5E Surgical/Transplant Critical Care, Department of Neurosurgery, Emory University Hospital, 1364 Clifton Road Northeast, 2nd Floor, 2D ICU- D264, Atlanta, GA 30322, USA; Department of Neurology, Emory University Hospital, 1364 Clifton Road Northeast, 2nd Floor, 2D ICU- D264, Atlanta, GA 30322, USA.

Critical Care and Hepatology, Emory University, 1364 Clifton Road Northeast, 2nd Floor, 2D ICU- D264, Atlanta, GA 30322, USA.

出版信息

Crit Care Clin. 2019 Jan;35(1):135-150. doi: 10.1016/j.ccc.2018.08.003.

DOI:10.1016/j.ccc.2018.08.003

PMID:30447776

Abstract

Extracorporeal liver support (ECLS) emerged from the need stabilize high-acuity liver failure patients with the highest risk of death. The goal is to optimize the hemodynamic, neurologic, and biochemical parameters in preparation for transplantation or to facilitate spontaneous recovery. Patients with acute liver failure and acute-on-chronic liver failure stand to benefit from these devices, especially because they have lost many of the primary functions of the liver, including detoxifying the blood of various endogenous and exogenous substances, manufacturing circulating proteins, secreting bile, and storing energy. Existing ECLS devices are designed to mimic some of these functions.

摘要

体外肝脏支持（ECLS）源于稳定具有最高死亡风险的高急性肝功能衰竭患者的需求。目标是优化血流动力学、神经学和生化参数，为移植做准备或促进自发恢复。急性肝功能衰竭和慢加急性肝功能衰竭患者可能会从这些设备中受益，特别是因为他们已经失去了肝脏的许多主要功能，包括清除血液中的各种内源性和外源性物质、制造循环蛋白、分泌胆汁和储存能量。现有的ECLS设备旨在模拟其中一些功能。