Moore Paul A, Hersh Elliot V
Pharmacology, Dental Public Health, University of Pittsburgh School of Dental Medicine, 386 Salk Hall, Pittsburgh, PA 15261, USA.
Department of Oral Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, 240 South 40th Street, Philadelphia, PA 19104-6030, USA.
Dent Clin North Am. 2019 Jan;63(1):35-44. doi: 10.1016/j.cden.2018.08.004.
It has been known for centuries that opioids are highly addictive when consumed for prolonged periods of time. Pharmacologic tolerance to the efficacy of opioid analgesic results in a need for increased dosing and drug dependence. One must question the empirical sources of evidence that justified the belief that prescription opioids were safe and effective for treating acute and chronic pain. Progress in developing and applying evidence-based analgesic therapies for acute inflammatory pain is presented.
几个世纪以来，人们都知道阿片类药物长期服用极易上瘾。对阿片类镇痛药疗效产生的药理学耐受性导致需要增加剂量并产生药物依赖性。人们必然会质疑那些证明处方阿片类药物治疗急性和慢性疼痛安全有效的证据的经验来源。本文介绍了在开发和应用基于证据的急性炎症性疼痛镇痛疗法方面取得的进展。
