选择性组织雌激素活性调节剂治疗后圆锥角膜的迟发性进展。
Late-onset progression of keratoconus after therapy with selective tissue estrogenic activity regulator.
机构信息
Laboratory for Ocular Cell Biology, Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Switzerland; ELZA Institute, Dietikon, Switzerland; Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil.
USC Roski Eye Institute, University of Southern California, Los Angeles, California, USA.
出版信息
J Cataract Refract Surg. 2019 Jan;45(1):101-104. doi: 10.1016/j.jcrs.2018.08.036. Epub 2018 Nov 14.
We describe the association of rapid progression of keratoconus in a 49-year-old woman on selective tissue estrogenic activity regulator (STEAR) therapy for endometriosis. Approximately 4 months after initiation of therapy with STEAR therapy and 3 months after ovariectomy, Scheimpflug images showed a massive increase in the previously stable ectasia. During this period, the maximum increase in the keratometry values was 2.7 diopters (D) in the right eye and 3.8 D in the left eye. Corneal crosslinking (CXL) was performed in both eyes. This resulted in excessive flattening of 5.5 D in the right eye and 6.1 D in the left eye at 9 months postoperatively. Patients having STEAR therapy must be monitored closely for corneal changes.
我们描述了一名 49 岁女性在使用选择性组织雌激素活性调节剂（STEAR）治疗子宫内膜异位症期间，角膜环曲病迅速进展的情况。在开始使用 STEAR 治疗大约 4 个月后和卵巢切除术 3 个月后，Scheimpflug 图像显示先前稳定的扩张明显增加。在此期间，右眼的角膜曲率值最大增加了 2.7 屈光度（D），左眼增加了 3.8 D。双眼均进行了角膜交联（CXL）。术后 9 个月，右眼的角膜压平量达到 5.5 D，左眼达到 6.1 D。使用 STEAR 治疗的患者必须密切监测角膜变化。
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