Laboratory for Ocular Cell Biology, Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Switzerland; ELZA Institute, Dietikon, Switzerland; Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil.
USC Roski Eye Institute, University of Southern California, Los Angeles, California, USA.
J Cataract Refract Surg. 2019 Jan;45(1):101-104. doi: 10.1016/j.jcrs.2018.08.036. Epub 2018 Nov 14.
We describe the association of rapid progression of keratoconus in a 49-year-old woman on selective tissue estrogenic activity regulator (STEAR) therapy for endometriosis. Approximately 4 months after initiation of therapy with STEAR therapy and 3 months after ovariectomy, Scheimpflug images showed a massive increase in the previously stable ectasia. During this period, the maximum increase in the keratometry values was 2.7 diopters (D) in the right eye and 3.8 D in the left eye. Corneal crosslinking (CXL) was performed in both eyes. This resulted in excessive flattening of 5.5 D in the right eye and 6.1 D in the left eye at 9 months postoperatively. Patients having STEAR therapy must be monitored closely for corneal changes.
我们描述了一名 49 岁女性在使用选择性组织雌激素活性调节剂（STEAR）治疗子宫内膜异位症期间，角膜环曲病迅速进展的情况。在开始使用 STEAR 治疗大约 4 个月后和卵巢切除术 3 个月后，Scheimpflug 图像显示先前稳定的扩张明显增加。在此期间，右眼的角膜曲率值最大增加了 2.7 屈光度（D），左眼增加了 3.8 D。双眼均进行了角膜交联（CXL）。术后 9 个月，右眼的角膜压平量达到 5.5 D，左眼达到 6.1 D。使用 STEAR 治疗的患者必须密切监测角膜变化。
