Neuro-innovation Technology & Brain Mapping Laboratory, Federal University of Piauí, Av. São Sebastião n°2819, Nossa Sra. de Fátima, Parnaíba, PI, 64202-020, Brazil.
Genetics and Molecular Biology Laboratory, Federal University of Piauí, Parnaíba, Brazil.
J Mol Neurosci. 2019 Jan;67(1):82-88. doi: 10.1007/s12031-018-1212-1. Epub 2018 Nov 17.
Studies at the molecular level aim to integrate genetic and neurobiological data to provide an increasingly detailed understanding of phenotypes related to the synchronization ability and brain oscillations in time perception. Genetic variation as a modifying factor at cellular and neurochemical levels permeates several neurofunctional aspects in time-lapse duration concentrating from milliseconds to hours. Thus, the review presents the BDNF Val66Met polymorphism association in a dynamic frame of brain neurotrophic factor expression in the adaptation, integrity, and neuronal synchronism processes in the ability to estimate multisensory stimuli at different time intervals. Our study aims to understand the molecular aspects involved in a neurobiological domain pertinent to the time judgment, tracing a genetic profile of association with psychometric functions and behavioral performances related to timing stimuli.
在分子水平上的研究旨在整合遗传和神经生物学数据，以提供对与同步能力和时间感知中的脑振荡相关的表型的日益详细的理解。遗传变异作为细胞和神经化学水平上的调节因子，渗透到时间跨度从毫秒到小时的几个神经功能方面。因此，该综述以大脑神经营养因子表达的动态框架呈现 BDNF Val66Met 多态性与适应、完整性和神经元同步过程中的关联，以估计不同时间间隔的多感觉刺激。我们的研究旨在理解与时间判断相关的神经生物学领域中的分子方面，追踪与时间刺激相关的心理测量功能和行为表现的遗传特征。
