Third Department of Neurology, G. Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
J Clin Neurosci. 2011 Dec;18(12):1744-5. doi: 10.1016/j.jocn.2011.03.015. Epub 2011 Oct 15.
Brain-derived neurotrophic factor (BDNF) enhances survival of dopaminergic neurons in the substantia nigra, whereas in patients with Parkinson's disease (PD), the expression of BDNF mRNA is decreased, thus making BDNF a candidate gene for PD susceptibility. The association between BDNF Val66Met polymorphism and PD has been evaluated in several studies with controversial results. Thus, we determined the distribution of BDNF Val66Met polymorphism in 184 Greek patients with sporadic PD and 113 control participants using polymerase chain reaction-restriction fragment length polymorphism, and explored the association of the polymorphism with certain clinical parameters of the disease. Our results do not support a major role for the BDNF Val66Met polymorphism in PD in the Greek population.
脑源性神经营养因子（BDNF）可增强黑质中多巴胺能神经元的存活，而在帕金森病（PD）患者中，BDNF mRNA 的表达减少，因此 BDNF 成为 PD 易感性的候选基因。BDNF Val66Met 多态性与 PD 的关联已在几项研究中进行了评估，但结果存在争议。因此，我们使用聚合酶链反应-限制性片段长度多态性来确定 184 名希腊散发性 PD 患者和 113 名对照参与者中 BDNF Val66Met 多态性的分布，并探讨了该多态性与该疾病某些临床参数的关联。我们的结果不支持 BDNF Val66Met 多态性在希腊人群 PD 中的主要作用。
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