Medicina de Aparato Digestivo, Hospital Universitario 12 de octubre, España.
Hospital Universitario 12 de octubre.
Rev Esp Enferm Dig. 2019 Feb;111(2):159-161. doi: 10.17235/reed.2018.5528/2018.
The use of direct-acting antivirals (DAA) for the hepatitis C virus (HCV) has yielded a significant improvement in the treatment of autoimmune hepatitis (AIH) associated with HCV infection. Interferon was the cornerstone of HCV therapy before the introduction of these agents into the clinical practice. Herein, we report the case of an HCV-infected patient who developed an interferon-induced AIH and since then, has received immunosuppressive therapy. Administration of DAA resulted in a sustained virologic response (SVR) and clinical AIH remission which allowed a discontinuation of immunosuppressive treatment.
直接作用抗病毒药物（DAA）在治疗丙型肝炎病毒（HCV）感染相关自身免疫性肝炎（AIH）方面取得了显著进展。在这些药物引入临床实践之前，干扰素是 HCV 治疗的基石。在此，我们报告了一例感染 HCV 的患者，该患者发生了干扰素诱导的 AIH，此后一直接受免疫抑制治疗。DAA 的使用导致了持续病毒学应答（SVR）和临床 AIH 缓解，从而可以停止免疫抑制治疗。
