Clermont Auvergne University, EA 3533, Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), Clermont-Ferrand, France.
PEPITE EA4267, and Exercise Performance Health Innovation Platform Univ. Bourgogne Franche-Comté, Besançon, France.
Arch Physiol Biochem. 2020 Oct;126(4):320-325. doi: 10.1080/13813455.2018.1534243. Epub 2018 Nov 17.
Neuregulin 1 (NRG1) and ErbB receptors are involved in glucose homeostasis. However, the effects of the neuregulin 1-ErbB pathway activation on glucose metabolism in liver are controversial. Assess NRG1 and ErbB signalling in liver and the effects of 8-week treatment with NRG1 on glucose homeostasis in diabetic db/db mice and in control healthy mice. NRG1 improved glucose, insulin and insulin sensitivity index during OGTT in db/db mice, but not in control mice. Compared with healthy mice, phosphorylation of p38, ErbB-1 and ErbB-3 was increased in diabetic mice, and neuregulin 1 treatment increased phosphorylation of p38 and ErbB-4. Conversely, the AKT/FOXO1 pathway was not affected by the 8-week treatment with NRG1. Diabetic mice showed altered NRG1-ErbB pathway in the liver compared with healthy mice. Moreover, chronic NRG1 treatment increased p38 phosphorylation in liver and improved glucose tolerance in diabetic mice, but not in control mice.
神经调节蛋白 1（NRG1）和 ErbB 受体参与葡萄糖稳态。然而，NRG1-ErbB 通路激活对肝脏葡萄糖代谢的影响存在争议。评估 NRG1 和 ErbB 信号在肝脏中的作用，以及 NRG1 对糖尿病 db/db 小鼠和对照健康小鼠 8 周治疗后葡萄糖稳态的影响。NRG1 改善了 db/db 小鼠 OGTT 期间的葡萄糖、胰岛素和胰岛素敏感指数，但对对照小鼠没有影响。与健康小鼠相比，糖尿病小鼠的 p38、ErbB-1 和 ErbB-3 磷酸化增加，NRG1 治疗增加了 p38 和 ErbB-4 的磷酸化。相反，AKT/FOXO1 通路不受 NRG1 治疗 8 周的影响。与健康小鼠相比，糖尿病小鼠肝脏中的 NRG1-ErbB 通路发生改变。此外，慢性 NRG1 治疗增加了肝脏中 p38 的磷酸化，改善了糖尿病小鼠的葡萄糖耐量，但对对照小鼠没有影响。
