Zak J P, Miller J A, Sheehan D V, Fanous B S
Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medicine, University of South Florida Psychiatry Center, Tampa 33613.
J Clin Psychiatry. 1988 Aug;49 Suppl:23-9.
The authors examine the role of the serotonergic system in the modulation or genesis of obsessive compulsive disorder and the potential for the use of the new serotonin (5-HT) reuptake inhibitors in its treatment. The data available are still preliminary, but are accumulating rapidly, and appear to hold promise in helping to understand this disorder and treat it more effectively. An overview of the data available is presented to assist in the planning of future research in this subject area. At least six major questions need to be addressed by future work: (1) What are the major hypotheses regarding the involvement of the serotonin system in the modulation or genesis of OCD? (2) Is there a serotonin system defect associated with OCD? (3) Is a serotonin system defect the underlying cause of OCD? (4) Are serotonin reuptake inhibitors effective in the treatment of OCD? (5) Are the effects of the serotonin reuptake inhibitors that are effective in treating OCD mediated via the serotonin system or via another mechanism? and (6) Are these drugs worth pursuing as treatment of OCD?
作者们研究了血清素能系统在强迫症的调节或发病机制中的作用，以及使用新型血清素（5-羟色胺，5-HT）再摄取抑制剂治疗强迫症的潜力。现有数据仍属初步，但正在迅速积累，似乎有望帮助我们更好地理解这种疾病并更有效地进行治疗。本文对现有数据进行了综述，以协助规划该领域未来的研究。未来的研究至少需要解决六个主要问题：（1）关于血清素系统参与强迫症调节或发病机制的主要假说是哪些？（2）是否存在与强迫症相关的血清素系统缺陷？（3）血清素系统缺陷是强迫症的根本原因吗？（4）血清素再摄取抑制剂对强迫症治疗有效吗？（5）对治疗强迫症有效的血清素再摄取抑制剂的作用是通过血清素系统介导还是通过其他机制介导？以及（6）这些药物作为强迫症的治疗手段值得探索吗？
