Fijałkowski Maciej, Stępniewska Joanna, Domański Maciej, Ciechanowski Kazimierz, Golembiewska Edyta
Pomeranian Medical University, Department of Nephrology, Transplantology and Internal Medicine.
Acta Biochim Pol. 2018 Nov 19;65(4):479-486. doi: 10.18388/abp.2018_2609.
Eicosanoids are biologically active molecules that are created in the process of oxidation of arachidonic acid (AA) which is a constituent of the cell membrane phospholipids. Throughout the years it was evidenced by experiments that the lipid and lipid-derived metabolites play an important role in physiological and pathological processes in the kidneys. They are being considered as biomarkers in detecting acute kidney injury, nephrotoxicity, glomerulonephritis and early stages of diabetic nephropathy because of their participation in inflammatory processes and in oxidative stress. They might be also considered as potential novel targets of therapy. However, the role of eicosanoids is still not fully clear and needs to be explored in future studies. In this brief review, studies on the role of eicosanoids in physiological and pathological conditions, e.g. acute kidney injury (AKI) and chronic kidney disease (CKD), and in different renal replacement therapies, including kidney transplantation, are being discussed.
类二十烷酸是具有生物活性的分子，在细胞膜磷脂的组成成分花生四烯酸（AA）的氧化过程中产生。多年来，实验证明脂质及其衍生代谢产物在肾脏的生理和病理过程中发挥着重要作用。由于它们参与炎症过程和氧化应激，因此被视为检测急性肾损伤、肾毒性、肾小球肾炎和糖尿病肾病早期阶段的生物标志物。它们也可能被视为潜在的新型治疗靶点。然而，类二十烷酸的作用仍不完全清楚，需要在未来的研究中进一步探索。在这篇简短的综述中，将讨论关于类二十烷酸在生理和病理状况（如急性肾损伤（AKI）和慢性肾脏病（CKD））以及不同肾脏替代治疗（包括肾移植）中的作用的研究。
