催产素及催产素受体在乳腺癌发病机制中的预防作用
Preventive effects of oxytocin and oxytocin receptor in breast cancer pathogenesis.
作者信息
Ariana Mehdi, Pornour Majid, Mehr Saeedeh Sarafraz, Vaseghi Hajar, Ganji Shahla Mohammad, Alivand Mohammad R, Salari Maryam, Akbari Mohammad E
机构信息
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Photo Healing & Regeneration, Medical Laser Research Center, Yara Institute, Academic Center for Education, Culture & Research (ACECR), Tehran, Iran.
出版信息
Per Med. 2019 Jan;16(1):25-34. doi: 10.2217/pme-2018-0009. Epub 2018 Nov 19.
AIM
Modifications of oxytocin (OT) concentration and OT receptor (OXTR) expression level have different effects on breast cancer-derived cells. This study was conducted to evaluate OT variation in breast cancer patients and to evaluate OXTR expression changes in breast cancer tissues.
METHODS
The plasma concentrations of OT in both breast cancer patients and healthy individuals' samples were assessed. OXTR variations were then assessed in both cancerous and noncancerous breast tissues.
RESULTS
OT had an increase in breast cancer patients and expression of OXTR in contralateral breast was more than cancerous tissues.
CONCLUSION
Despite the high levels of OT concentration in breast cancer patients, it seems that a lower expression of OXTR in cancerous tissues can be effective in the breast cancer progression.
目的
催产素（OT）浓度的改变和OT受体（OXTR）表达水平的变化对乳腺癌衍生细胞有不同影响。本研究旨在评估乳腺癌患者体内OT的变化，并评估乳腺癌组织中OXTR表达的变化。
方法
评估乳腺癌患者和健康个体样本中OT的血浆浓度。然后评估癌性和非癌性乳腺组织中的OXTR变化。
结果
乳腺癌患者体内OT升高，且对侧乳腺中OXTR的表达高于癌组织。
结论
尽管乳腺癌患者体内OT浓度较高，但癌组织中OXTR表达较低似乎可能在乳腺癌进展中起作用。
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