Shibutani Y, Sakamoto K, Katsuno S, Yoshimoto S, Matsuura T
Department of Hygiene, Hyogo College of Medicine, Japan.
J Hypertens. 1988 Jun;6(6):489-93. doi: 10.1097/00004872-198806000-00009.
Plasma renin activity (PRA) was determined in a group of 610 Japanese schoolchildren aged 10-14 years in order to investigate the relationship between PRA distribution and a family history of hypertension. Plasma renin activity was higher in the subjects with a family history of hypertension (FH+) than in those without a family history of hypertension (FH-). Systolic blood pressure (SBP) was also higher in the FH+ group than in the FH- group. The FH- group showed a significant negative correlation between PRA and SBP (boys, r = -0.254, P less than 0.01; girls, r = -0.225, P less than 0.01), whereas the FH+ group showed no correlation between PRA and blood pressure. These results suggested that schoolchildren with a family history of hypertension might have an enhanced renin-aldosterone (R-A) system, resulting in elevation of blood pressure.
为了研究血浆肾素活性（PRA）分布与高血压家族史之间的关系，对一组610名年龄在10至14岁的日本学童进行了血浆肾素活性测定。有高血压家族史（FH+）的受试者的血浆肾素活性高于无高血压家族史（FH-）的受试者。FH+组的收缩压（SBP）也高于FH-组。FH-组的PRA与SBP之间存在显著负相关（男孩，r = -0.254，P<0.01；女孩，r = -0.225，P<0.01），而FH+组的PRA与血压之间无相关性。这些结果表明，有高血压家族史的学童可能具有增强的肾素-醛固酮（R-A）系统，从而导致血压升高。
