白细胞介素-33，一种在肿瘤微环境中表达的潜在细胞因子，通过促进 CD8 T 细胞参与抗肿瘤免疫治疗。
Interleukin-33, a Potential Cytokine Expressed in Tumor Microenvironment Involves in Antitumor Immunotherapy Through Facilitates CD8 T Cells.
机构信息
1 Department of Immunology, School of Biology and Basic Medical Sciences, Soochow University , Suzhou, China .
2 Department of Clinical Laboratory, Suzhou No. 7 People's Hospital , Suzhou, China .
出版信息
J Interferon Cytokine Res. 2018 Nov;38(11):491-499. doi: 10.1089/jir.2018.0069.
Interleukin-33 (IL-33) is a cytokine with pleiotropic functions in various diseases; however, its role in the antitumor immune response is still unclear. We found the expression of IL-33/ST2 in nonsmall cell lung tumor microenvironment. Furthermore, we found that IL-33 promoted effector functions of CD8 T cells that play a critical role in antitumor immune response. In addition, we found that IL-33 enhanced tumor vaccine effector functions in mice. Altogether, these findings suggest that IL-33, through facilitates CD8 T cells in microenvironment to provide a profound effect in antitumor immunotherapy.
白细胞介素-33（IL-33）是一种在各种疾病中具有多种功能的细胞因子；然而，它在抗肿瘤免疫反应中的作用尚不清楚。我们发现白细胞介素-33/ST2 在非小细胞肺癌肿瘤微环境中的表达。此外，我们发现白细胞介素-33 促进了在抗肿瘤免疫反应中起关键作用的 CD8 T 细胞的效应功能。此外，我们发现白细胞介素-33 增强了小鼠肿瘤疫苗的效应功能。总之，这些发现表明，白细胞介素-33 通过促进微环境中的 CD8 T 细胞在抗肿瘤免疫治疗中发挥深远的作用。
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