移植物的长期存留对诱导耐受而言是一种不充分的刺激。研究环孢素在大鼠I类抗原不相合心脏移植物中的作用。
Long-term residence of a graft is an insufficient stimulus for the induction of tolerance. Investigating the role of cyclosporine in class I-disparate heart grafts in the rat.
作者信息
Lim S M, White D J
机构信息
Department of Surgery, Addenbrookes Hospital, Cambridge, United Kingdom.
出版信息
J Exp Med. 1988 Aug 1;168(2):807-10. doi: 10.1084/jem.168.2.807.
Abstract
This study demonstrates that the induction of tolerance is possible across a class I only antigenic barrier that fails to produce heart graft rejection. However, the long-term residence alone of such a graft per se, does not necessarily lead to the establishment of systemic tolerance in the recipient. The important finding in this study with regard to the biology of allograft tolerance, is that while the class I antigen provides the stimulus, its presence alone is not sufficient for the induction of tolerance; indeed, the action of the Cyclosporine A (CyA) is a necessary adjunct to its induction.
摘要
本研究表明，在仅缺乏能引发心脏移植排斥反应的I类抗原屏障的情况下，诱导免疫耐受是可能的。然而，此类移植本身的长期留存并不一定会导致受体建立全身免疫耐受。关于同种异体移植耐受生物学，本研究的重要发现是，虽然I类抗原提供了刺激，但仅其存在并不足以诱导免疫耐受；实际上，环孢素A（CyA）的作用是诱导免疫耐受的必要辅助条件。
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引用本文的文献
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本文引用的文献
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Antigen dependence of cyclosporin A-induced allograft acceptance.
Transplantation. 1982 Oct;34(4):216-8. doi: 10.1097/00007890-198210000-00012.
2
Effect of class II antigen matching on renal allograft survival in miniature swine.II类抗原匹配对小型猪同种异体肾移植存活的影响。
J Exp Med. 1984 Nov 1;160(5):1495-508. doi: 10.1084/jem.160.5.1495.
3
A technique for accessory cervical heart transplantation in rabbits and rats.一种在兔和大鼠中进行副颈心脏移植的技术。
Acta Pathol Microbiol Scand A. 1971;79(4):366-72. doi: 10.1111/j.1699-0463.1971.tb01833.x.
4
Identifying a susceptible period following cyclosporine A-induced tolerance of heart grafts in the rat.确定环孢素A诱导大鼠心脏移植耐受后的易感期。
Transplant Proc. 1987 Oct;19(5):4218-20.
5
Specific unresponsiveness in rats with prolonged allograft survival is dependent upon the graft and suppressor T cells.同种异体移植长期存活大鼠的特异性无反应性取决于移植物和抑制性T细胞。
Transplant Proc. 1987 Feb;19(1 Pt 1):495-6.
6
Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Mediation of specific suppression by T helper/inducer cells.环孢素治疗后心脏同种异体移植长期存活大鼠的特异性无反应性。辅助性T/诱导细胞介导的特异性抑制作用。
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7
A recombinant in the major histocompatibility complex of the rat.大鼠主要组织相容性复合体中的一种重组体。
Nature. 1977 Mar 24;266(5600):362-4. doi: 10.1038/266362a0.
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Nature of the unresponsiveness induced by cyclosporin A in rats bearing renal allografts.
Transplantation. 1979 Nov;28(5):439-41. doi: 10.1097/00007890-197911000-00023.
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