"Petru Poni" Institute of Macromolecular Chemistry, Romanian Academy, 41 A, Gr. Ghica Voda Alley, 700487 Iasi, Romania.
Gheorghe Asachi Technical University, "Cristofor Simionescu" Faculty of Chemical Engineering and Environmental Protection, 73 Prof. dr. docent Dimitrie Mangeron Street, 700050 Iasi, Romania.
Int J Biol Macromol. 2019 Feb 15;123:744-751. doi: 10.1016/j.ijbiomac.2018.11.107. Epub 2018 Nov 17.
A new approach for the preparation of poly (vinyl alcohol) (PVA) - cellulose based composite hydrogels by freezing/thawing method was conceived. We synthesized firstly the tricarboxy cellulose (OxC) (bearing three carboxyl groups in one anhydroglucose unit) using a one shot oxidation procedure and subsequently, the aqueous solutions of OxC were mixed with PVA solutions in different ratios, in the absence of any supplementary cross-linking agent. The spectral methods, FTIR, H, C NMR, as well as rheology measurements were used to assess the degree of interaction between the two components. The morphology studies of the resulted hydrogels, performed by SEM shows an excellent distribution of the tricarboxy cellulose inside the PVA matrix, the addition of tricarboxy cellulose contributing to an increase of the pore size. The rheological investigation reveals the synergistic network when an optimum amount of tricarboxy cellulose was introduced. In addition, the self-healing behavior reveals by the viscoelastic behavior, strongly recommend these hydrogels as potential candidates in tissue engineering applications.
我们设想了一种通过冷冻/解冻法制备聚乙烯醇（PVA）-纤维素基复合水凝胶的新方法。我们首先使用一步氧化法合成了三羧酸纤维素（OxC）（一个无水葡萄糖单元中含有三个羧基），然后在没有任何额外交联剂的情况下，将 OxC 的水溶液与 PVA 溶液以不同的比例混合。光谱方法、FTIR、H、C NMR 以及流变学测量用于评估两种成分之间的相互作用程度。通过 SEM 进行的所得水凝胶的形态研究表明，三羧酸纤维素在 PVA 基质内的分布非常好，三羧酸纤维素的添加有助于增加孔径。流变学研究表明，当引入最佳量的三羧酸纤维素时，会形成协同网络。此外，通过粘弹性行为揭示的自修复行为强烈推荐这些水凝胶作为组织工程应用的潜在候选材料。
