College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Natural Products and Alternative Medicines, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
J Ethnopharmacol. 2019 Mar 1;231:179-186. doi: 10.1016/j.jep.2018.11.023. Epub 2018 Nov 16.
Debregeasia salicifolia Rendle (DS) is used traditionally for the treatment of several diseases including; urinary system diseases, bone fractures, boils, diarrhea accompanied with blood, carbuncles, pimples, dermatitis, skin rash, eczema, and tumors. Additionally, it is used as an antiseptic and antifungal agent.
To document up to date information regarding D. salicifolia and link the traditional uses with its reported pharmacological evidences. The review covers taxonomy, distribution, traditional uses, active phytochemical constituents and pharmacological activities for DS.
The electronic databases such as Google Scholar, E-Resource Portal of Imam Abdulrahman bin Faisal University, Scopus, PubMed, Springer Link, etc. as well as textbooks were used to gather all relevant information about DS.
Ethnomedicinal studies revealed a wide use of DS for various traditional purposes in the south Asian community. The uses for diarrhea, cancer, urinary complaints and skin diseases were supported by pharmacological studies. In-vitro pharmacological studies confirmed its therapeutic activities e.g. antimicrobial, anticancer, and antioxidant. Moreover, analgesic and anti-diarrheal activities were also established in animal's in-vivo activities. Despite enormous literature regarding DS, the main focus of research and interest was antimicrobial and cytotoxic activities. Quantitative and qualitative phytochemical analysis proved the presence of various classes of phytochemicals in DS extract; triterpenes, phytosterols, tannins, flavonoids and anthraquinone.
Though most of the traditional uses for the plant were supported by in-vitro and in-vivo pharmacological studies, however lack of clinical trials and shortage of in-depth mechanistic in-vivo studies was noted in the review. Hence, more elaborative in-vivo studies with quality clinical trials may be focused in order to confirm the safety and efficacy of reported activities in humans which will help explore the plant's therapeutic potentials.
Debregeasia salicifolia Rendle（DS）传统上用于治疗多种疾病，包括泌尿系统疾病、骨折、痈、带血腹泻、痈疖、粉刺、皮炎、皮疹、湿疹和肿瘤。此外，它还用作防腐剂和抗真菌剂。
记录有关 D. salicifolia 的最新信息，并将传统用途与其报道的药理学证据联系起来。综述涵盖了 DS 的分类学、分布、传统用途、活性植物化学成分和药理学活性。
使用电子数据库，如 Google Scholar、Imam Abdulrahman bin Faisal 大学的电子资源门户、Scopus、PubMed、Springer Link 等，以及教科书，收集有关 DS 的所有相关信息。
民族医学研究表明，DS 在南亚社区中因其各种传统用途而被广泛使用。腹泻、癌症、尿路疾病和皮肤病的用途得到了药理学研究的支持。体外药理学研究证实了其治疗活性，如抗菌、抗癌和抗氧化作用。此外，在动物体内研究中也证实了其镇痛和抗腹泻活性。尽管有大量关于 DS 的文献，但研究和关注的主要焦点是抗菌和细胞毒性活性。定量和定性植物化学分析证明了 DS 提取物中存在各种类别的植物化学成分，如三萜类、植物甾醇、单宁、类黄酮和蒽醌。
尽管该植物的大多数传统用途都得到了体外和体内药理学研究的支持，但在综述中注意到缺乏临床试验和深入的体内机制研究。因此，可能需要更详细的体内研究，并进行高质量的临床试验，以确认报道的活性在人类中的安全性和有效性，这将有助于探索该植物的治疗潜力。
