Permiakov N K, Galankina I E
Kardiologiia. 1988 May;28(5):33-6.
Morphologic studies of coronary arterial thrombi have shown immature fibrin fibres to prevail in those, with fibrin degradation products always present. This fact suggests that fibrinolytic components of hemostasis, limiting the rates of fibrin polymerization and maturation, may participate in thrombogenesis. At the same time, macrophages that phagocytose fibrin and blood cells (platelets and erythrocytes) become activated since the early hours of the thrombus' existence. Selective administration of fibrinolytic activators destroys the fibrin network of the thrombus, blood cells are washed away by the blood flow and the thrombus diminishes in volume. At the same time, its macrophagal response is activated, and fibrin and fibrin degradation products are eliminated from the vascular lumen.
冠状动脉血栓的形态学研究表明，在这些血栓中未成熟的纤维蛋白纤维占主导，且始终存在纤维蛋白降解产物。这一事实表明，止血的纤溶成分限制了纤维蛋白聚合和成熟的速率，可能参与了血栓形成过程。与此同时，吞噬纤维蛋白和血细胞（血小板和红细胞）的巨噬细胞自血栓形成的早期就开始被激活。选择性给予纤溶激活剂会破坏血栓的纤维蛋白网络，血细胞被血流冲走，血栓体积减小。与此同时，其巨噬细胞反应被激活，纤维蛋白和纤维蛋白降解产物从血管腔中清除。
