Hua Xin, Zhu Xiaoli
Medical College of Southeast University, Affiliated Zhongda Hospital of Southeast University, Nanjing 210000, China.
Department of Respiration, Affiliated Zhongda Hospital of Southeast University, Nanjing 210000, China.
Zhongguo Fei Ai Za Zhi. 2018 Nov 20;21(11):868-874. doi: 10.3779/j.issn.1009-3419.2018.11.09.
Non-small cell lung cancer (NSCLC) is one of the malignant tumors with highest mortality in the world, it is still a difficult problem in clinical field. Its occurrence and development are closely associated with tumor angiogenesis. Angiopoietin-2 (Ang-2) is an important angiogenesis factor that has involved in many researches and it has been confirmed that the expression of Ang-2 is significantly up-regulated in tissues and blood of NSCLC. Meanwhile, Ang-2 is related to malignant biological behavior of cancer cells, making it a potential biological marker for the diagnosis and prognosis of NSCLC. At present, researches on Ang-2 how to promote the progression of NSCLC around the world are focused on Ang-2 regulating the proliferation, invasion, and metastasis of NSCLC. This paper summarized and estimated the studies and literature reports of regulatory mechanisms of Ang-2 in NSCLC, hopefully it could help looking for targeted drug treatment of Ang-2 in the future. .
非小细胞肺癌（NSCLC）是全球死亡率最高的恶性肿瘤之一，仍是临床领域的难题。其发生发展与肿瘤血管生成密切相关。血管生成素-2（Ang-2）是一种重要的血管生成因子，已参与多项研究，且已证实其在NSCLC组织和血液中的表达显著上调。同时，Ang-2与癌细胞的恶性生物学行为相关，使其成为NSCLC诊断和预后的潜在生物学标志物。目前，全球关于Ang-2如何促进NSCLC进展的研究主要集中在Ang-2对NSCLC增殖、侵袭和转移的调控方面。本文总结并评估了Ang-2在NSCLC中调控机制的研究及文献报道，希望有助于未来寻找针对Ang-2的靶向药物治疗。
