感染相关性肾小球肾炎

Infection-Related Glomerulonephritis.

作者信息

Hunt Elizabeth A K, Somers Michael J G

机构信息

Division of Pediatric Nephrology, University of Vermont Children's Hospital, Larner College of Medicine, UVM Medical Center, 111 Colchester Avenue, Smith 5, Burlington, VT 05405, USA.

Division of Nephrology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

出版信息

Pediatr Clin North Am. 2019 Feb;66(1):59-72. doi: 10.1016/j.pcl.2018.08.005.

DOI:10.1016/j.pcl.2018.08.005

PMID:30454751

Abstract

Acute postinfectious glomerulonephritis or infection-related glomerulonephritis has been associated with several viral or bacterial infections. Group A beta-hemolytic streptococcal infection is the prototypical cause of postinfectious glomerulonephritis and the main focus of this discussion. The clinical spectrum can vary widely, from asymptomatic microscopic hematuria incidentally detected on routine urinalysis to rapidly progressive glomerulonephritis with acute kidney injury requiring emergent dialysis. Other important causes include glomerulonephritis associated with endocarditis and ventriculoatrial shunt infections. Multiple renal pathologic conditions have been associated with hepatitis B and C infections.

摘要

急性感染后肾小球肾炎或感染相关性肾小球肾炎与多种病毒或细菌感染有关。A组β溶血性链球菌感染是感染后肾小球肾炎的典型病因，也是本次讨论的主要焦点。临床谱差异很大，从常规尿液分析偶然发现的无症状镜下血尿到伴有急性肾损伤需要紧急透析的快速进展性肾小球肾炎。其他重要病因包括与心内膜炎和心室心房分流感染相关的肾小球肾炎。多种肾脏病理状况与乙型和丙型肝炎感染有关。