Department of Student Affairs, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
6620 Main Street, Suite 1425, Houston, TX 77030, USA.
Clin Liver Dis. 2019 Feb;23(1):127-139. doi: 10.1016/j.cld.2018.09.007.
Alcoholic liver disease is a serious and increasing contributor to the global liver disease burden. Extensive selection criteria, including a minimum abstinence period, has previously been used to secure good outcomes but new research questions the effectiveness of abstinence periods and has recommended changes in integrated alcohol use treatment to effectively prevent relapse. Patients have unique health concerns, including posttransplantation risks of malignancy and metabolic complications, but overall very good long-term outcomes. Severe alcoholic hepatitis has been increasingly treated with early transplantation without a set sobriety period, with overall favorable outcomes, even with respect to recidivism.
酒精性肝病是导致全球肝病负担的一个严重且日益严重的因素。以前，为了确保良好的结果，广泛使用了包括最低戒酒期在内的严格选择标准，但新的研究质疑了戒酒期的有效性，并建议改变酒精使用综合治疗，以有效地预防复发。患者有独特的健康问题，包括移植后的恶性肿瘤和代谢并发症风险，但总体来说，长期预后非常好。严重的酒精性肝炎越来越多地采用早期移植而无需设定戒酒期进行治疗，总体结果良好，甚至在复发方面也是如此。
