Department of Cardiac and Thoracic Vascular Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Luebeck, Germany.
Department of Cardiac and Thoracic Vascular Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Luebeck, Germany.
J Thorac Cardiovasc Surg. 2018 Dec;156(6):2076-2082.e2. doi: 10.1016/j.jtcvs.2018.05.096. Epub 2018 Jun 12.
Optimal treatment of the dissected root in type A dissection is still controversial. Valve-sparing techniques offer the advantage of better valve performance compared with mechanical valves or bioprostheses. The role of the different valve-preserving methods-root repair and replacement-needs further evaluation.
Follow-up data (median follow-up, 11.4 years; 95% confidence interval [CI], 10.1-12.7; range, 0-22.1 years) of 179 patients with acute type A dissection and root involvement, who underwent a valve-sparing root replacement using reimplantation (n = 44) or remodeling (n = 39) or a valve-sparing root repair (n = 96) between 1993 and 2017 were analyzed with respect to survival and reoperation.
Median age of patients with reimplantation was 56.9 (range, 20.2-78), with remodeling 62.6 (range, 31-79.1), and with valve-sparing root repair 64.5 (range, 31-89.6) years. Thirty-day mortality for these groups was 15.9%, 15.4%, and 12.5% (P = .829), late mortality at 15 years was 43.2% (95% CI, 28.1-66.5), 36.7% (95% CI, 19.7-68.1), and 36.5% (95% CI, 23.0-57.9; P = .504). Risk factors for overall mortality were age, connective tissue disease, total arch replacement, surgical time, cross-clamp time, circulatory arrest, and the reimplantation technique. Cumulative incidence of reoperation at 15 years was 13.4% (95% CI, 2.1-24.7), 20% (95% CI, 6.3-33.6), and 13.3% (95% CI, 4.8-21.7; P = .565), respectively.
With the different conditions in each group in this study on patients with acute type A dissection the valve-preserving root repair technique has similar long-term rates of survival and reoperation compared with root replacement techniques, underlining its usefulness as a less complex and even faster surgical technique if individually indicated.
A型夹层中被解剖的根部的最佳治疗方法仍存在争议。与机械瓣膜或生物假体相比,保留瓣膜技术具有更好的瓣膜性能优势。不同的保留瓣膜方法——根部修复和替换——的作用需要进一步评估。
对 1993 年至 2017 年间接受保留瓣膜根部替换术的 179 例急性 A 型夹层合并根部受累患者的随访数据(中位随访时间 11.4 年;95%置信区间 [CI],10.1-12.7;范围,0-22.1 年)进行分析,这些患者接受了再植入术(n=44)、成形术(n=39)或保留瓣膜根部修复术(n=96)。分析了生存率和再次手术的情况。
再植入组患者的中位年龄为 56.9 岁(范围,20.2-78 岁),成形术组为 62.6 岁(范围,31-79.1 岁),保留瓣膜根部修复组为 64.5 岁(范围,31-89.6 岁)。这些组的 30 天死亡率分别为 15.9%、15.4%和 12.5%(P=0.829),15 年时的晚期死亡率分别为 43.2%(95%CI,28.1-66.5)、36.7%(95%CI,19.7-68.1)和 36.5%(95%CI,23.0-57.9;P=0.504)。总死亡率的危险因素为年龄、结缔组织疾病、全弓置换、手术时间、体外循环时间、停循环时间和再植入技术。15 年时再次手术的累积发生率分别为 13.4%(95%CI,2.1-24.7)、20%(95%CI,6.3-33.6)和 13.3%(95%CI,4.8-21.7;P=0.565)。
在这项研究中,由于每组患者的具体情况不同,急性 A 型夹层患者保留瓣膜根部修复技术与根部替换技术相比具有相似的长期生存率和再次手术率,这凸显了其作为一种不那么复杂甚至更快的手术技术的有用性,如果单独指征合适的话。