Dupre Tess V, Siskind Leah J
Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, 85719, USA.
Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA; James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA.
Adv Biol Regul. 2018 Dec;70:31-39. doi: 10.1016/j.jbior.2018.11.003. Epub 2018 Nov 13.
Acute kidney injury (AKI) is most simply defined as the rapid loss of kidney function in a matter of hours to days. AKI can manifest in a number of ways including pre-renal, post-renal, or intrinsic AKI. During acute kidney injury, multiple pathogenic processes are activated including inflammation, cell death, and the generation of reactive oxygen species, just to name a few. Sphingolipids are known to play a role in a number of the pathogenic pathways involved in the pathogenesis of many types of AKI, which suggests a role for sphingolipids in AKI. This short review will discuss the evidence for a role for sphingolipids in AKI.
急性肾损伤（AKI）最简单的定义是在数小时至数天内肾功能迅速丧失。AKI可通过多种方式表现出来，包括肾前性、肾后性或内在性AKI。在急性肾损伤期间，多种致病过程被激活，包括炎症、细胞死亡和活性氧的产生，仅举几例。已知鞘脂在多种类型AKI发病机制中涉及的许多致病途径中起作用，这表明鞘脂在AKI中发挥作用。这篇简短的综述将讨论鞘脂在AKI中发挥作用的证据。
