McTier Tom L, Pullins Aleah, Chapin Sara, Rugg Jady, von Reitzenstein Marcela, McCall John W, King Vickie L, Vatta Adriano F
Zoetis, Veterinary Medicine Research and Development, 333 Portage Street, Kalamazoo, MI, 49007, USA.
Zoetis, Veterinary Medicine Research and Development, 333 Portage Street, Kalamazoo, MI, 49007, USA.
Vet Parasitol. 2019 Jun;270:56-62. doi: 10.1016/j.vetpar.2018.10.010. Epub 2018 Oct 15.
Three controlled studies were conducted to investigate the efficacy of selamectin plus sarolaner (Revolution Plus/Stronghold Plus) in preventing feline heartworm disease in cats. In all studies, cats were inoculated with 100 Dirofilaria immitis third stage larvae on Day -30. In the first study, cats were treated with selamectin plus sarolaner as a single dose on Day 0 or as three consecutive monthly doses on Days 0, 28 and 56. In the second and third studies, cats were treated with either sarolaner alone on Day 0, selamectin plus sarolaner on Day 0 or selamectin plus sarolaner as three consecutive monthly doses on Days 0, 28 and 56. In all three studies, dosages were 6 mg/kg selamectin plus 1 mg/kg sarolaner or 1 mg/kg sarolaner alone. Control cats were given a placebo containing inert formulation ingredients (vehicle). All treatments were administered at a single site topically to the skin cranial to the scapulae. Cats were humanely euthanized on Day 145/146 (i.e., 175/176 post-inoculation), and adult D. immitis worms were recovered and enumerated. Across the three studies, adult heartworms were recovered from 87 to 100% of control cats, with geometric mean worm counts ranging from 2.1 to 5.4. No adult D. immitis worms were recovered from cats treated with selamectin plus sarolaner. Cats treated with sarolaner alone were not protected against D. immitis infection, showing geometric mean worm counts of 1.9 to 2.4. In these studies, selamectin (6 mg/kg) plus sarolaner (1 mg/kg) was 100% effective in preventing heartworm development in cats when administered topically as one dose 30 days after inoculation or as three consecutive monthly doses starting 30 days post-inoculation. These studies demonstrated that a single topical administration of selamectin plus sarolaner at the recommended dosage was completely effective in preventing the development of D. immitis in cats.
开展了三项对照研究，以调查塞拉菌素加沙罗拉纳（瑞辉加强版/司倍牢加强版）预防猫心丝虫病的疗效。在所有研究中，猫在第 -30 天接种 100 条犬恶丝虫第三期幼虫。在第一项研究中，猫在第 0 天接受塞拉菌素加沙罗拉纳单剂量治疗，或在第 0、28 和 56 天接受连续三个月的每月一次剂量治疗。在第二项和第三项研究中，猫在第 0 天单独接受沙罗拉纳治疗，或在第 0 天接受塞拉菌素加沙罗拉纳治疗，或在第 0、28 和 56 天接受连续三个月的每月一次剂量的塞拉菌素加沙罗拉纳治疗。在所有三项研究中，剂量为 6 毫克/千克塞拉菌素加 1 毫克/千克沙罗拉纳或仅 1 毫克/千克沙罗拉纳。对照猫给予含有惰性制剂成分（赋形剂）的安慰剂。所有治疗均在肩胛上方的皮肤单个部位进行局部给药。猫在第 145/146 天（即接种后 175/176 天）实施安乐死，回收并计数成年犬恶丝虫。在三项研究中，87% 至 100% 的对照猫体内回收了成年心丝虫，几何平均虫数在 2.1 至 5.4 之间。接受塞拉菌素加沙罗拉纳治疗的猫未回收成年犬恶丝虫。单独接受沙罗拉纳治疗的猫未受到犬恶丝虫感染的保护，几何平均虫数为 1.9 至 2.4。在这些研究中，接种后 30 天局部给予一次剂量或接种后 30 天开始连续三个月每月一次剂量的 6 毫克/千克塞拉菌素加 1 毫克/千克沙罗拉纳，对预防猫心丝虫发育的有效率为 100%。这些研究表明，按推荐剂量单次局部给予塞拉菌素加沙罗拉纳可完全有效预防猫体内犬恶丝虫的发育。
