Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
EMBO J. 2018 Dec 3;37(23). doi: 10.15252/embj.2018100801. Epub 2018 Nov 19.
The production of ribosomes plays a central role in regulating cell cycle progression and cancer proliferation. A new study by Gaviraghi (2018) shows that mRNA decapping coactivator PNRC1 acts as a tumor suppressor by regulating ribosome biogenesis. PNRC1 relocalizes the Dcp1/Dcp2 mRNA decapping complex to the nucleolus and promotes decapping of specific snoRNAs to disrupt the processing of ribosomal RNA. By slowing rRNA processing, and thus ribosome biogenesis, PNRC1 acts as a gatekeeper that restrains oncogenic potential.
核糖体的生成在调控细胞周期进程和癌症增殖方面起着核心作用。Gaviraghi（2018）的一项新研究表明，mRNA 去帽共激活因子 PNRC1 通过调节核糖体生物发生来发挥肿瘤抑制因子的作用。PNRC1 将 Dcp1/Dcp2 mRNA 去帽复合物重新定位到核仁，并促进特定 snoRNA 的去帽，从而破坏核糖体 RNA 的加工。通过减缓 rRNA 的加工，从而抑制核糖体的生物发生，PNRC1 作为一种“守门员”，抑制致癌潜能。
