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BAP1 regulates different mechanisms of cell death.

作者信息

Affar El Bachir, Carbone Michele

机构信息

Maisonneuve-Rosemont Hospital Research Center, Department of Medicine, University of Montréal, Montréal, Quebec, H1T 2M4, Canada.

Hawaii Cancer Center, Honolulu, Hawai'i, 96813, USA.

出版信息

Cell Death Dis. 2018 Nov 19;9(12):1151. doi: 10.1038/s41419-018-1206-5.

DOI:10.1038/s41419-018-1206-5
PMID:30455474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6242853/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa69/6242853/e63efc5a8f6e/41419_2018_1206_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa69/6242853/e63efc5a8f6e/41419_2018_1206_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa69/6242853/e63efc5a8f6e/41419_2018_1206_Fig1_HTML.jpg

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Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.自泛素化保护肿瘤抑制因子 BAP1 免于被非典型泛素连接酶 UBE2O 介导的细胞质隔离。
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BAP1 regulates IP3R3-mediated Ca flux to mitochondria suppressing cell transformation.BAP1调节IP3R3介导的钙流入线粒体,从而抑制细胞转化。
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4
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BAP1 has a survival role in cutaneous melanoma.BAP1在皮肤黑色素瘤中具有生存作用。
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本文引用的文献

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Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1.ASXLs 的单泛素化控制肿瘤抑制因子 BAP1 的去泛素化酶活性。
Nat Commun. 2018 Oct 22;9(1):4385. doi: 10.1038/s41467-018-06854-2.
2
BAP1 links metabolic regulation of ferroptosis to tumour suppression.BAP1 将铁死亡代谢调控与肿瘤抑制联系起来。
Nat Cell Biol. 2018 Oct;20(10):1181-1192. doi: 10.1038/s41556-018-0178-0. Epub 2018 Sep 10.
3
The Cappadocia mesothelioma epidemic: its influence in Turkey and abroad.卡帕多西亚间皮瘤疫情:其在土耳其国内外的影响。
Front Oncol. 2025 Jan 23;15:1495617. doi: 10.3389/fonc.2025.1495617. eCollection 2025.
4
Bayesian analysis of the rate of spontaneous malignant mesothelioma among BAP1 mutant mice in the absence of asbestos exposure.在无石棉暴露情况下对BAP1突变小鼠自发性恶性间皮瘤发生率的贝叶斯分析。
Sci Rep. 2025 Jan 2;15(1):169. doi: 10.1038/s41598-024-84069-w.
5
Extraction and Prioritization of a Gene-Cancer-By-Survival Network Involved in Homeostasis of Intracellular Calcium Concentrations Using TCGA PANCAN Data.利用TCGA泛癌数据提取和优先排序参与细胞内钙浓度稳态的基因-癌症-生存网络
Bioelectricity. 2022 May 26;4(2):92-102. doi: 10.1089/bioe.2022.0013. eCollection 2022 May.
6
Ferroptosis in Renal Cancer Therapy: A Narrative Review of Drug Candidates.肾癌治疗中的铁死亡:候选药物的叙述性综述
Cancers (Basel). 2024 Sep 11;16(18):3131. doi: 10.3390/cancers16183131.
7
Saturation genome editing of BAP1 functionally classifies somatic and germline variants.饱和基因组编辑功能分类体细胞和种系变体的 BAP1。
Nat Genet. 2024 Jul;56(7):1434-1445. doi: 10.1038/s41588-024-01799-3. Epub 2024 Jul 5.
8
Therapeutic Strategies to Improve the Treatment of Pleural Mesothelioma.改善胸膜间皮瘤治疗的治疗策略
Curr Med Chem. 2025;32(11):2093-2114. doi: 10.2174/0109298673268206240405084558.
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Cardiovasc Diabetol. 2024 Apr 2;23(1):116. doi: 10.1186/s12933-024-02183-5.
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Cancer Res. 2024 Jun 4;84(11):1747-1763. doi: 10.1158/0008-5472.CAN-23-3298.
Ann Transl Med. 2017 Jun;5(11):239. doi: 10.21037/atm.2017.04.06.
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Germline BAP1 mutations induce a Warburg effect.胚系 BAP1 突变可诱导瓦博格效应。
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BAP1 regulates IP3R3-mediated Ca flux to mitochondria suppressing cell transformation.BAP1调节IP3R3介导的钙流入线粒体,从而抑制细胞转化。
Nature. 2017 Jun 22;546(7659):549-553. doi: 10.1038/nature22798. Epub 2017 Jun 14.
6
Consensus Report of the 2015 Weinman International Conference on Mesothelioma.2015年温曼国际间皮瘤会议共识报告
J Thorac Oncol. 2016 Aug;11(8):1246-1262. doi: 10.1016/j.jtho.2016.04.028.
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Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s.基因与系谱学联合研究发现一个可追溯至18世纪一位共同祖先的九代庞大BAP1癌症综合征家族。
PLoS Genet. 2015 Dec 18;11(12):e1005633. doi: 10.1371/journal.pgen.1005633. eCollection 2015 Dec.
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The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer.BAP1/ASXL2组蛋白H2A去泛素化酶复合物调控细胞增殖并在癌症中失调。
J Biol Chem. 2015 Nov 27;290(48):28643-63. doi: 10.1074/jbc.M115.661553. Epub 2015 Sep 28.
9
Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.自泛素化保护肿瘤抑制因子 BAP1 免于被非典型泛素连接酶 UBE2O 介导的细胞质隔离。
Mol Cell. 2014 May 8;54(3):392-406. doi: 10.1016/j.molcel.2014.03.002. Epub 2014 Apr 3.
10
Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair.抑癌基因和去泛素化酶 BAP1 促进 DNA 双链断裂修复。
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):285-90. doi: 10.1073/pnas.1309085110. Epub 2013 Dec 17.