The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
Nanomedicine (Lond). 2018 Nov;13(22):2939-2955. doi: 10.2217/nnm-2018-0167. Epub 2018 Nov 20.
With a special size and structure, nanoparticles (NPs) have excellent application prospects in various fields and are widely used in the biomedicine, cosmetics and chemical industries nowadays. However, there have been some reports on the biosafety of this new type of material, pointing out its cytotoxicity in inducing apoptosis. With different physicochemical properties in size, shape, surface charge, and ligand, NPs exhibit different biocompatibilities when interacting with different cells. Therefore, a comprehensive and deep study into the proapoptotic mechanism of NPs is necessary. In the present review, we summarize the NP-triggered apoptotic signal pathways in detail and highlight some important functional molecules involved. We hope our findings and perspectives provide a new direction for the sound development of nanotechnology in the future.
由于具有特殊的尺寸和结构，纳米颗粒（NPs）在各个领域具有优异的应用前景，目前已广泛应用于生物医药、化妆品和化学工业。然而，这种新型材料的生物安全性已经有一些报道，指出其在诱导细胞凋亡方面的细胞毒性。由于在尺寸、形状、表面电荷和配体等方面具有不同的理化性质，纳米颗粒与不同细胞相互作用时表现出不同的生物相容性。因此，全面深入地研究纳米颗粒的促凋亡机制是必要的。在本综述中，我们详细总结了 NPs 触发的细胞凋亡信号通路，并强调了一些涉及的重要功能分子。我们希望我们的发现和观点为纳米技术的未来健康发展提供一个新的方向。
