Singh Anamika, Srivastava Ved
Intarcia Therapeutic, Inc. 6 Davis Drive, Research Triangle Park, Durham, NC 27709, United States.
Applied Physical Sciences, University of North Carolina-Chapel Hill, Chapel Hill, NC-27599, United States.
Protein Pept Lett. 2018;25(12):1090-1100. doi: 10.2174/0929866525666181120090857.
Peptides are recognized as highly specific and efficacious molecules, thus have found increasing use in developing therapeutics in recent years. It has also been realized that pathophyisology of diseases are very complex and targeting multiple pathways often result in better outcome. The therapeutic potential of a single entity multifunctional peptides that act on two or more distinct receptors with the complementary mechanism of action to gain additive or synergistic benefit compared to monotherapy has been exploited in various disease areas. Herein, we reviewed the therapeutic potential of multifunctional peptides with examples from the field of metabolic, cardiovascular and neuropathic pain disease.
肽被认为是高度特异性和有效的分子，因此近年来在开发治疗药物方面的应用越来越广泛。人们也已经认识到，疾病的病理生理学非常复杂，针对多种途径往往会带来更好的治疗效果。单一实体的多功能肽作用于两个或更多不同受体，通过互补的作用机制获得与单一疗法相比的累加或协同益处，其治疗潜力已在各个疾病领域得到利用。在此，我们通过代谢、心血管和神经性疼痛疾病领域的实例，综述了多功能肽的治疗潜力。
