Clinic for Child and Adolescent Psychiatry and Psychotherapy, University Medical Center, Göttingen, Germany.
Service for Child and Adolescent Psychiatry Thurgau, Romanshorn, Switzerland.
PLoS One. 2018 Nov 20;13(11):e0207522. doi: 10.1371/journal.pone.0207522. eCollection 2018.
A previous study (Roessner et al. 2007) found psychopathological evidence of an additive model of the comorbid group with Chronic Tic Disorders and Attention Deficit Hyperactivity Disorder (CTD+ADHD), which demanded clinical interventions aimed primarily at the factor ADHD. This 14-year follow-up study tested whether this childhood additive model can also be found in young adulthood and whether ADHD remains the most impairing factor.
92 patients (22.8% girls) from Roessner et al. (2007) were re-investigated as young adults at the age of 24 years, broken down into four groups: CTD-only (n = 22), CTD+ADHD (n = 23), ADHD-only (n = 24), and controls (n = 23). The Adult Behavior Checklist (ABCL) was used as an equivalent parent-report instrument to the Child Behavior Checklist (CBCL) applied 14 years ago. Statistically, 2x2 factorial design was completed.
From the point of view of parents, the factors CTD and ADHD in young adults contributed almost equally to psychopathological problems and showed many interactions, i.e. an interactive model was supported. In addition, the ADHD factor was no longer the leading problem for psychosocial impairment in the adult CTD+ADHD group.
The additive model of CTD+ADHD seems to exist no longer in young adults, nor may the childhood predominance of the factor ADHD in comorbid CTD+ADHD. Thus, treatment priority should be decided by clinicians on a case-by-case basis depending on the most impairing disorder of each patient.
先前的一项研究(Roessner 等人,2007 年)发现了慢性抽动障碍和注意缺陷多动障碍(CTD+ADHD)共病组的精神病理学证据,表明存在叠加模型,这需要针对 ADHD 这一主要因素进行临床干预。本项为期 14 年的随访研究检验了这一儿童期叠加模型是否也能在青年期找到,以及 ADHD 是否仍然是最具损害性的因素。
Roessner 等人(2007 年)的研究中的 92 名患者(22.8%为女孩)在 24 岁时作为青年期被重新评估,分为四组:CTD 组(n=22)、CTD+ADHD 组(n=23)、ADHD 组(n=24)和对照组(n=23)。采用成人行为检查表(ABCL)作为与 14 年前应用的儿童行为检查表(CBCL)等效的家长报告工具。采用 2x2 析因设计进行统计分析。
从家长的角度来看,青少年期的 CTD 和 ADHD 这两个因素几乎同样导致精神病理学问题,且存在许多相互作用,即支持交互模型。此外,ADHD 因素不再是成年 CTD+ADHD 组社会心理损害的主要问题。
CTD+ADHD 的叠加模型似乎在青年期不复存在,也可能不再存在儿童期 ADHD 因素在 CTD+ADHD 中的优势。因此,应根据每位患者最具损害性的疾病,由临床医生逐个病例决定治疗的优先顺序。