Laboratory of Innovative Medicine, School of Biological and Medical Physics, Moscow Institute of Physics and Technology, Institutsky per., 9, 141701 Dolgoprudny, Moscow Region, Russia.
Ageing Res Rev. 2019 Jan;49:11-26. doi: 10.1016/j.arr.2018.11.002. Epub 2018 Nov 17.
The mortality rates of age-related diseases (ARDs) increase exponentially with age. Processes described by the exponential growth function typically involve a branching chain reaction or, more generally, a positive feedback loop. Here I propose that each ARD is mediated by one or several positive feedback loops (vicious cycles). I then identify critical vicious cycles in five major ARDs: atherosclerosis, hypertension, diabetes, Alzheimer's and Parkinson's. I also propose that the progression of ARDs can be halted by selectively interrupting the vicious cycles and suggest the most promising targets.
与年龄相关的疾病（ARDs）的死亡率随年龄呈指数级增长。指数增长函数描述的过程通常涉及分支链式反应，或者更一般地说，涉及正反馈循环。在这里，我提出每个 ARD 都是由一个或多个正反馈循环（恶性循环）介导的。然后，我确定了五个主要的 ARD 中的关键恶性循环：动脉粥样硬化、高血压、糖尿病、阿尔茨海默病和帕金森病。我还提出，通过选择性地中断恶性循环，可以阻止 ARD 的进展，并提出了最有希望的目标。
