Mathé G, Halle-Pannenko O, Bourut C
Recent Results Cancer Res. 1977(62):9-12. doi: 10.1007/978-3-642-81174-6_3.
Cyclophosphamide (CPM) chemotherapy (134 mg/kg) of L1210 leukemia is less efficient in mice previously immunodepressed by antithymocyte serum (ATS) than in non-ATS pretreated mice. On the other hand, administration of a higher dose of CPM (403 mg/kg), which kills a greater number of leukemic cells but induces an immunodepression, according to the skin graft test, results in a shorter survival time than does the administration of a lower dose of CPM (134 mg/kg), capable of killing fewer leukemic cells but not inducing such an immunodepression. Thus, it appears that: (1) the antileukemic effect of the same dose of a chemotherapeutic drug is less efficient in immunodepressed than in nonimmunodepressed hosts, and (2) calculation of the number of neoplastic cells killed by a given chemotherapy by extrapolation from the survival time may lead to erroneous conclusions.
环磷酰胺（CPM）对L1210白血病的化疗（134毫克/千克），在先前用抗胸腺细胞血清（ATS）免疫抑制的小鼠中，其效率低于未用ATS预处理的小鼠。另一方面，根据皮肤移植试验，给予更高剂量的CPM（403毫克/千克），虽然能杀死更多的白血病细胞，但会诱导免疫抑制，与给予较低剂量的CPM（134毫克/千克）相比，其存活时间更短。较低剂量的CPM能杀死较少的白血病细胞，但不会诱导这种免疫抑制。因此，似乎：（1）相同剂量的化疗药物的抗白血病作用在免疫抑制宿主中比在非免疫抑制宿主中效率更低；（2）通过从存活时间外推来计算给定化疗杀死的肿瘤细胞数量可能会得出错误的结论。
