Department of Medical Sciences, University of Alberta, Canada.
J Infect Public Health. 2019 Mar-Apr;12(2):242-246. doi: 10.1016/j.jiph.2018.10.014. Epub 2018 Nov 17.
As one of the most debilitating and underdiagnosed hereditary conditions across the globe, cystic fibrosis requires intensive support from the healthcare system - particularly due to the increased susceptibility to chronic infection and resulting respiratory failure which can rapidly lead to death. In turn, the prevalence and action of a certain strain of bacterium - Pseudomonas aeruginosa - has gained a great deal of interest. Life-threatening chronic infections by P. aeruginosa have been shown to involve biofilm formation, proliferation and the release of quorum-sensing signaling molecules. Understanding the mechanism cascade by which this strain attacks cells within the respiratory epithelium, most notably airway epithelial cells, could offer insight into the pathway and components, which are attractive targets for therapeutic interventions.
囊性纤维化是全球最具致残性和漏诊率的遗传性疾病之一，需要医疗系统的大力支持 - 特别是由于其对慢性感染的易感性增加以及由此导致的呼吸衰竭，这可能会迅速导致死亡。反过来，一种特定的细菌 - 铜绿假单胞菌的流行和作用引起了极大的关注。已表明铜绿假单胞菌引起的危及生命的慢性感染涉及生物膜形成、增殖和群体感应信号分子的释放。了解该菌株攻击呼吸道上皮细胞（尤其是气道上皮细胞）内细胞的机制级联反应，可以深入了解该途径和成分，这些途径和成分是治疗干预的有吸引力的靶点。
