Moore Michael, Pembroke Ann, Nestler Eric, Hall Maurice, Lefkovitz Lisa, Lambert Mark, Keay Kenneth
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA.
Dis Aquat Organ. 2018 Nov 20;131(3):239-243. doi: 10.3354/dao03299.
Chemical carcinogen biomarkers can validate public investment in environmental remediation. A major factor driving the clean-up of Boston Harbor, MA, USA, induced by the federal Clean Water Act legislation of 1972, was the high prevalence of petroleum and halogenated aromatic hydrocarbon contaminant-associated liver neoplasia in winter flounder Pseudopleuronectes americanus in the harbor in the 1980s. In the present study, we examined the spatial and temporal relationships between the suspended solids and contaminants in the municipal sewage discharge, and liver neoplasia and histopathology in flounder, from 1987 to 2017. Toxics source reduction, sewage treatment, and sludge removal in the 1990s and outfall relocation offshore in 2000 enabled a decreasing prevalence of persistent toxic chemicals in flounder, effluent, and sediment, and consequent disappearance of liver neoplasia and reduction of neoplasm-associated, hydropically vacuolated biliary epithelial cells to background levels. This supports long-term investment in elimination and treatment of anthropogenic waste streams and the value of federal regulatory mandates to maintain and improve regional environmental quality.
化学致癌物生物标志物可以验证在环境修复方面的公共投资。1972年美国联邦《清洁水法》立法促使美国马萨诸塞州波士顿港进行清理，一个主要因素是20世纪80年代该港口美洲黄盖鲽（Pseudopleuronectes americanus）中与石油和卤代芳烃污染物相关的肝肿瘤高发。在本研究中，我们研究了1987年至2017年城市污水排放中的悬浮固体和污染物与比目鱼肝脏肿瘤及组织病理学之间的时空关系。20世纪90年代的减少有毒物质排放、污水处理和污泥清除，以及2000年排污口向近海迁移，使得比目鱼、废水和沉积物中持久性有毒化学物质的患病率降低，肝肿瘤随之消失，与肿瘤相关的、水样空泡化的胆管上皮细胞减少到背景水平。这支持了在消除和处理人为废物流方面的长期投资，以及联邦监管指令对于维持和改善区域环境质量的价值。
