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来自马萨诸塞州波士顿港的美洲拟庸鲽（Pseudopleuronectes americanus）体内的肿瘤和非肿瘤性肝脏病变。

Neoplasms and nonneoplastic liver lesions in winter flounder, Pseudopleuronectes americanus, from Boston Harbor, Massachusetts.

作者信息

Murchelano R A, Wolke R E

机构信息

National Marine Fisheries Service, Northeast Fisheries Center, Woods Hole, MA 02543.

出版信息

Environ Health Perspect. 1991 Jan;90:17-26. doi: 10.1289/ehp.90-1519495.

DOI:10.1289/ehp.90-1519495
PMID:1646709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1519495/
Abstract

A variety of neoplasms and nonneoplastic hepatic lesions have been noted in winter flounder, Pseudopleuronectes americanus, from Boston Harbor, Massachusetts. Inflammatory lesions include cholangiitis, pericholangiitis, pericholangial fibrosis, hepatitis, and pancreatitis. Necrotic lesions consist essentially of focal coagulative necrosis and a distinctive vacuolated cell lesion of the hepatic parenchyma. The most conspicuous and numerous proliferative lesion is macrophage aggregate hyperplasia and hypertrophy. Preneoplastic lesions include principally basophilic foci of cellular alteration and hepatocellular adenoma. Carcinomas consist of several morphologic varieties: hepatocarcinoma, cholangiocarcinoma, and anaplastic adenocarcinoma. The pathogenesis of the lesions observed is discussed with respect to anthropogenically introduced chemical contaminants and the resistant hepatocyte model of hepatocarcinogenesis. This study, and others of bottom-living food fish with enzootic neoplastic disease, warrants further evaluation, particularly with respect to possible bioaccumulation of chemical contaminants in edible tissues.

摘要

在马萨诸塞州波士顿港的美洲拟庸鲽（Pseudopleuronectes americanus）中，已发现多种肿瘤和非肿瘤性肝脏病变。炎症性病变包括胆管炎、胆管周炎、胆管周围纤维化、肝炎和胰腺炎。坏死性病变主要由局灶性凝固性坏死和肝实质中一种独特的空泡化细胞病变组成。最显著且数量最多的增殖性病变是巨噬细胞聚集增生和肥大。癌前病变主要包括细胞改变的嗜碱性灶和肝细胞腺瘤。癌有几种形态学类型：肝癌、胆管癌和间变性腺癌。针对人为引入的化学污染物和肝癌发生的抗性肝细胞模型，对所观察到的病变的发病机制进行了讨论。这项研究以及其他关于患有地方流行性肿瘤疾病的底栖食用鱼类的研究，值得进一步评估，特别是关于可食用组织中化学污染物可能的生物积累方面。

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