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PhoPR介导的对磷限制反应的激活受[具体物种]中壁磷壁酸代谢的调控。

Activation of the PhoPR-Mediated Response to Phosphate Limitation Is Regulated by Wall Teichoic Acid Metabolism in .

作者信息

Devine Kevin M

机构信息

Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.

出版信息

Front Microbiol. 2018 Nov 6;9:2678. doi: 10.3389/fmicb.2018.02678. eCollection 2018.

DOI:10.3389/fmicb.2018.02678
PMID:30459743
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6232261/
Abstract

Phosphorous is essential for cell viability. To ensure an adequate supply under phosphate limiting conditions, bacteria induce a cohort of enzymes to scavenge for phosphate, and a high affinity transporter for its uptake into the cell. This response is controlled by a two-component signal transduction system named PhoBR in and PhoPR in . PhoR is a sensor kinase whose activity is responsive to phosphate availability. Under phosphate limiting conditions, PhoR exists in kinase mode that phosphorylates its cognate response regulator (PhoB, PhoP). When activated, PhoB∼P/PhoP∼P execute changes in gene expression that adapt cells to the phosphate limited state. Under phosphate replete conditions, PhoR exists in phosphatase mode that maintains PhoB/PhoP in an inactive, non-phosphorylated state. The mechanism by which phosphate availability is sensed and how it controls the balance between PhoR kinase and phosphatase activities has been studied in and . Two different mechanisms have emerged. In the most common mechanism, PhoR activity is responsive to phosphate transport through a PstSCAB/PhoU signaling complex that relays the conformational status of the transporter to PhoR. In the second mechanism currently confined to , PhoR activity is responsive to wall teichoic acid metabolism whereby biosynthetic intermediates can promote or inhibit PhoR autokinase activity. Variations of both mechanisms are found that allow each bacterial species to adapt to phosphate availability in their particular environmental niche.

摘要

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/6232261/658e5b7084a6/fmicb-09-02678-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/6232261/abe88ec29da2/fmicb-09-02678-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/6232261/658e5b7084a6/fmicb-09-02678-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/6232261/abe88ec29da2/fmicb-09-02678-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/6232261/658e5b7084a6/fmicb-09-02678-g002.jpg

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Access Microbiol. 2023 Jun 12;5(6). doi: 10.1099/acmi.0.000508.v3. eCollection 2023.
5
Nutrient-Limited Operational Strategies for the Microbial Production of Biochemicals.微生物生产生物化学品的营养限制操作策略
Microorganisms. 2022 Nov 10;10(11):2226. doi: 10.3390/microorganisms10112226.
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A Genome-Wide CRISPR Interference Screen Reveals an StkP-Mediated Connection between Cell Wall Integrity and Competence in Streptococcus salivarius.全基因组 CRISPR 干扰筛选揭示了唾液链球菌细胞壁完整性和感受态之间的 StkP 介导的连接。
mSystems. 2022 Dec 20;7(6):e0073522. doi: 10.1128/msystems.00735-22. Epub 2022 Nov 7.
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Genome-Wide Analysis Reveals that PhoP Regulates Pathogenicity in Riemerella anatipestifer.全基因组分析揭示 PhoP 调控鸭疫里默氏菌的致病性。
Microbiol Spectr. 2022 Oct 26;10(5):e0188322. doi: 10.1128/spectrum.01883-22. Epub 2022 Oct 5.
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Streptomyces can be an excellent plant growth manager.链霉菌可以成为优秀的植物生长调节剂。
World J Microbiol Biotechnol. 2022 Aug 18;38(11):193. doi: 10.1007/s11274-022-03380-8.
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Deletion of the Response Regulator PhoP Accelerates the Formation of Aerial Mycelium and Spores in .应答调节因子PhoP的缺失加速了[具体菌种]中气生菌丝体和孢子的形成。 （原文中“in.”部分信息缺失，这里补充为“[具体菌种]”使句子完整）
Front Microbiol. 2022 Apr 6;13:845620. doi: 10.3389/fmicb.2022.845620. eCollection 2022.
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Complete Genome Sequence of sp. Strain INOP01, a Phosphate-Solubilizing Bacterium Isolated from an Agricultural Soil in Germany.从德国农业土壤中分离出的解磷细菌菌株INOP01的全基因组序列
Microbiol Resour Announc. 2022 Apr 21;11(4):e0020722. doi: 10.1128/mra.00207-22. Epub 2022 Apr 4.
PhoU2而非PhoU1作为表皮葡萄球菌生物膜形成和对多种应激耐受性的重要调节因子，通过参与各种基本代谢过程发挥作用。
J Bacteriol. 2017 Nov 14;199(24). doi: 10.1128/JB.00219-17. Print 2017 Dec 15.
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Transporters as information processors in bacterial signalling pathways.转运蛋白作为细菌信号通路中的信息处理器
Mol Microbiol. 2017 Apr;104(1):1-15. doi: 10.1111/mmi.13633. Epub 2017 Feb 24.
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Identification of Two Phosphate Starvation-induced Wall Teichoic Acid Hydrolases Provides First Insights into the Degradative Pathway of a Key Bacterial Cell Wall Component.两种磷酸盐饥饿诱导的壁磷壁酸水解酶的鉴定为关键细菌细胞壁成分的降解途径提供了初步见解。
J Biol Chem. 2016 Dec 9;291(50):26066-26082. doi: 10.1074/jbc.M116.760447. Epub 2016 Oct 25.
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Physiological Roles of the Dual Phosphate Transporter Systems in Low and High Phosphate Conditions and in Capsule Maintenance of Streptococcus pneumoniae D39.双磷酸盐转运体系统在低磷和高磷条件下以及肺炎链球菌D39荚膜维持中的生理作用
Front Cell Infect Microbiol. 2016 Jun 20;6:63. doi: 10.3389/fcimb.2016.00063. eCollection 2016.
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Polyphosphate: popping up from oblivion.多聚磷酸盐：从被遗忘中崭露头角。
Curr Genet. 2017 Feb;63(1):15-18. doi: 10.1007/s00294-016-0611-5. Epub 2016 May 25.
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Identification of the PhoB Regulon and Role of PhoU in the Phosphate Starvation Response of Caulobacter crescentus.新月柄杆菌中PhoB调控子的鉴定及PhoU在磷酸盐饥饿应答中的作用
J Bacteriol. 2015 Oct 19;198(1):187-200. doi: 10.1128/JB.00658-15. Print 2016 Jan 1.
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The Pho regulon: a huge regulatory network in bacteria.Pho 调控子：细菌中的一个庞大调控网络。
Front Microbiol. 2015 Apr 30;6:402. doi: 10.3389/fmicb.2015.00402. eCollection 2015.
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Genetic analysis, structural modeling, and direct coupling analysis suggest a mechanism for phosphate signaling in Escherichia coli.遗传分析、结构建模和直接耦合分析揭示了大肠杆菌中磷酸盐信号传导的一种机制。
BMC Genet. 2015;16 Suppl 2(Suppl 2):S2. doi: 10.1186/1471-2156-16-S2-S2. Epub 2015 Apr 23.