Park Min Hee, Baek Bosung, Jin Hee Kyung, Bae Jae-Sung
Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, South Korea.
Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea.
Anim Cells Syst (Seoul). 2018 Sep 5;22(5):281-288. doi: 10.1080/19768354.2018.1517826. eCollection 2018.
Chemotherapy-induced bone marrow damage is accompanied by acute nerve injury in the bone marrow (BM), resulting in sensory and autonomic neuropathy. Cisplatin, a popular chemotherapy drugs, induces the impairment of hematopoietic stem cells (HSCs) and bone marrow regeneration, leading to chronic bone marrow abnormalities. Previously, we reported the protective roles of neuropeptide Y (NPY) against cisplatin-induced bone marrow impairment. In this study, we identified novel peptides, generated from full-length NPY that rescued cisplatin-induced sensory neuropathy and HSC suppression by regulating cell survival in the BM microenvironment. One of these peptides, especially, showed a better protective property against these impairments compared to that seen in full-length NPY. Therefore, we suggest the NPY sequences most effective against the chemotherapy-induced bone marrow dysfunction that could be potentially useful as therapeutic agents for patients receiving chemotherapy.
化疗引起的骨髓损伤伴有骨髓中的急性神经损伤，导致感觉和自主神经病变。顺铂是一种常用的化疗药物，可导致造血干细胞（HSC）损伤和骨髓再生障碍，从而引起慢性骨髓异常。此前，我们报道了神经肽Y（NPY）对顺铂诱导的骨髓损伤具有保护作用。在本研究中，我们鉴定了由全长NPY产生的新型肽，其通过调节骨髓微环境中的细胞存活来挽救顺铂诱导的感觉神经病变和HSC抑制。其中一种肽尤其显示出比全长NPY更好的针对这些损伤的保护特性。因此，我们提出了对化疗诱导的骨髓功能障碍最有效的NPY序列，其可能潜在地用作接受化疗患者的治疗剂。
