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Bortezomib consolidation post-ASCT as frontline therapy for multiple myeloma deepens disease response and MRD-negative rate whilst maintaining QOL and response to re-treatment at relapse.

作者信息

Cohen Oliver C, Counsell Nicholas, Rabin Neil, Popat Rakesh, Owen Roger G, Popova Bilyana, Schofield Oliver, Clifton-Hadley Laura, Lyons-Lewis Janet, Rawstron Andy, Spence Christopher, de Tute Ruth M, Hughes Derralynn, Moore Sally, Smith Paul, Yong Kwee L

机构信息

Haematology, University College London Hospitals NHS Foundation Trust, London, UK.

Cancer Research UK and UCL Cancer Trials Centre, London, UK.

出版信息

Br J Haematol. 2019 Jun;185(5):948-951. doi: 10.1111/bjh.15649. Epub 2018 Nov 20.

DOI:10.1111/bjh.15649
PMID:30460696
Abstract
摘要

相似文献

1
Bortezomib consolidation post-ASCT as frontline therapy for multiple myeloma deepens disease response and MRD-negative rate whilst maintaining QOL and response to re-treatment at relapse.
Br J Haematol. 2019 Jun;185(5):948-951. doi: 10.1111/bjh.15649. Epub 2018 Nov 20.
2
Bortezomib consolidation after autologous stem cell transplantation in multiple myeloma: a Nordic Myeloma Study Group randomized phase 3 trial.硼替佐米巩固治疗多发性骨髓瘤自体干细胞移植后：北欧骨髓瘤研究组随机 3 期试验。
Blood. 2013 Jun 6;121(23):4647-54. doi: 10.1182/blood-2012-11-464503. Epub 2013 Apr 24.
3
Lenalidomide vs bortezomib maintenance choice post-autologous hematopoietic cell transplantation for multiple myeloma.来那度胺与硼替佐米维持治疗多发性骨髓瘤自体造血干细胞移植后的选择。
Bone Marrow Transplant. 2018 Jun;53(6):701-707. doi: 10.1038/s41409-018-0177-6. Epub 2018 Apr 27.
4
Bortezomib consolidation following autologous transplant in younger and older patients with newly diagnosed multiple myeloma in two phase III trials.在两项 III 期临床试验中，年轻和老年新诊断多发性骨髓瘤患者在自体移植后接受硼替佐米巩固治疗。
Eur J Haematol. 2019 Sep;103(3):255-267. doi: 10.1111/ejh.13281. Epub 2019 Jul 19.
5
Real world experience of bortezomib re-treatment for patients with multiple myeloma at first relapse.硼替佐米对首次复发的多发性骨髓瘤患者进行再治疗的真实世界经验。
Br J Haematol. 2017 May;177(3):495-497. doi: 10.1111/bjh.14086. Epub 2016 Apr 8.
6
Modified HyperCVAD Versus Bortezomib-HyperCAD in Patients With Relapsed/Refractory Multiple Myeloma.改良HyperCVAD方案与硼替佐米-HyperCAD方案治疗复发/难治性多发性骨髓瘤患者的比较
Clin Lymphoma Myeloma Leuk. 2018 Jan;18(1):e77-e84. doi: 10.1016/j.clml.2017.10.008. Epub 2017 Nov 2.
7
Comparable outcome of stem cell transplant versus bortezomib-based consolidation in myeloma patients after major response to induction.在骨髓瘤患者诱导治疗取得主要缓解后，干细胞移植与基于硼替佐米的巩固治疗的疗效比较。
Hematology. 2013 Nov;18(6):341-7. doi: 10.1179/1607845413Y.0000000082. Epub 2013 Mar 16.
8
Response-adapted consolidation with bortezomib after ASCT improves progression-free survival in newly diagnosed multiple myeloma.自体造血干细胞移植（ASCT）后采用硼替佐米进行反应适应性巩固治疗可改善新诊断多发性骨髓瘤患者的无进展生存期。
Leukemia. 2017 Jun;31(6):1463-1466. doi: 10.1038/leu.2017.83. Epub 2017 Mar 15.
9
Effects of single-agent bortezomib as post-transplant consolidation therapy on multiple myeloma-related bone disease: a randomized phase II study.单药硼替佐米作为移植后巩固治疗对多发性骨髓瘤相关骨病的影响：一项随机II期研究。
Br J Haematol. 2017 Jul;178(1):61-71. doi: 10.1111/bjh.14637. Epub 2017 Apr 6.
10
[First-line treatment of multiple myeloma].[多发性骨髓瘤的一线治疗]
Internist (Berl). 2019 Jan;60(1):23-33. doi: 10.1007/s00108-018-0527-x.

引用本文的文献

1
Health-Related Quality of Life in Multiple Myeloma Patients Treated with High- or Low-Dose Lenalidomide Maintenance Therapy after Autologous Stem Cell Transplantation-Results from the LenaMain Trial (NCT00891384).自体干细胞移植后接受高剂量或低剂量来那度胺维持治疗的多发性骨髓瘤患者的健康相关生活质量——来自LenaMain试验（NCT00891384）的结果
Cancers (Basel). 2023 Oct 26;15(21):5157. doi: 10.3390/cancers15215157.
2
Continuous low-dose cyclophosphamide plus prednisone in the treatment of relapsed and refractory multiple myeloma with severe complications.持续低剂量环磷酰胺联合泼尼松治疗伴有严重并发症的复发难治性多发性骨髓瘤
Front Oncol. 2023 May 22;13:1185991. doi: 10.3389/fonc.2023.1185991. eCollection 2023.
3
Surveillance imaging during first remission in follicular lymphoma does not impact overall survival.
滤泡性淋巴瘤首次缓解期的监测性影像学检查并不影响总生存期。
Cancer. 2021 Sep 15;127(18):3390-3402. doi: 10.1002/cncr.33660. Epub 2021 Jun 22.