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自我明智、他人明智、街头明智(SOS)培训,一种预防双诊断患者受害的干预措施:一项随机临床试验的结果。

Self-wise, Other-wise, Streetwise (SOS) training, an intervention to prevent victimization in dual-diagnosis patients: results from a randomized clinical trial.

机构信息

Department of Psychiatry, Amsterdam Institute for Addiction Research, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Department of Research, Arkin Mental Health Care, Amsterdam, the Netherlands.

出版信息

Addiction. 2019 Apr;114(4):730-740. doi: 10.1111/add.14500. Epub 2018 Dec 18.

Abstract

BACKGROUND AND AIMS

Patients with co-occurring substance use and other mental disorders are vulnerable to crime victimization, yet no evidence-based preventive interventions exist. Our aim was to test the efficacy of a new intervention, Self-wise, Other-wise, Streetwise training (SOS training), to prevent victimization in these dual-diagnosis patients as an add-on to care as usual.

DESIGN

Multi-site single-blind parallel randomized controlled trial.

SETTING

Three sites within one psychiatric service in Amsterdam, the Netherlands.

PARTICIPANTS

Adult in-patients and out-patients with dual diagnosis (n = 250), who were predominantly male (70.4%), aged on average 42.1 years, and diagnosed with 3.7 DSM-IV disorders.

INTERVENTION AND COMPARATOR

Care as usual, consisting of pharmacotherapy combined with individual psychotherapy, group psychotherapy and/or supportive counselling (n = 125) was compared with care as usual plus SOS training: a 6-week, 12-session manualized group training focused on enhancing emotion regulation skills, conflict resolution skills and street skills (n = 125).

MEASUREMENTS

Victimization was assessed with the Safety Monitor, the Dutch equivalent of the International Crime Victims Survey, in a face-to-face assessment. The primary outcome measure was treatment response (yes/no), with 'yes' defined as reporting at least a 50% reduction in the number of past-year victimization incidents at the 14-month follow-up compared with baseline. Analyses were performed according to the intention-to-treat principle.

FINDINGS

The proportion of participants achieving treatment response for total victimization was 54.0% in the control group and 67.6% in the experimental group, a significant difference [odds ratio (OR) = 1.78, 95% confidence interval (CI) = 1.02-3.11, P = 0.042]. Treatment response for violent victimization was achieved by 68.7% of the control group and 79.3% of the experimental group (OR = 1.75, 95% CI = 0.91-3.34, P = 0.092). With a Bayes factor of 2.26, this result was inconclusive.

CONCLUSIONS

Among dual-diagnosis patients, care as usual plus Self-wise, Other-wise, Streetwise training was more effective in preventing victimization than care as usual alone.

摘要

背景和目的

同时患有物质使用障碍和其他精神障碍的患者容易成为犯罪受害者,但目前尚不存在基于证据的预防干预措施。我们的目的是测试一种新的干预措施——Self-wise、Other-wise、Streetwise 培训(SOS 培训)的疗效,该干预措施作为常规护理的附加措施,旨在预防这些双重诊断患者的受害。

设计

多地点单盲平行随机对照试验。

地点

荷兰阿姆斯特丹一家精神病服务机构的三个地点。

参与者

患有双重诊断的成年住院和门诊患者(n=250),他们主要为男性(70.4%),平均年龄 42.1 岁,被诊断患有 3.7 种 DSM-IV 障碍。

干预和对照组

常规护理包括药物治疗联合个体心理治疗、团体心理治疗和/或支持性咨询(n=125),与常规护理加 SOS 培训进行比较:为期 6 周、12 节的手册化小组培训,重点是增强情绪调节技能、冲突解决技能和街头技能(n=125)。

测量

通过面对面评估使用 Safety Monitor(荷兰版国际犯罪受害者调查)评估受害情况。主要结局指标为治疗反应(是/否),定义为与基线相比,14 个月随访时过去一年受害事件数量减少至少 50%。分析按照意向治疗原则进行。

结果

对照组和实验组中,总受害的治疗反应比例分别为 54.0%和 67.6%,差异具有统计学意义[比值比(OR)=1.78,95%置信区间(CI)=1.02-3.11,P=0.042]。对照组和实验组中,暴力受害的治疗反应比例分别为 68.7%和 79.3%(OR=1.75,95% CI=0.91-3.34,P=0.092)。贝叶斯因子为 2.26,结果不确定。

结论

在双重诊断患者中,常规护理加 Self-wise、Other-wise、Streetwise 培训比单独常规护理更能有效预防受害。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be9a/6590185/0ce50dbcd774/ADD-114-730-g001.jpg

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