Borisova A M, Koev D, Ovcharova N, Pasheeva V
Vutr Boles. 1988;27(1):93-7.
In the Scientific Institute for Endocrinology, Geriatrics and Gerontology, Sofia, 1723 diabetic patients were treated with insulin during the last 3 years. In 150 of them insulin allergy was supposed. The patients sensitivity toward the various insulin preparations was determined by intradermal test. Insulin allergy was found in 29 patients (1.68%). Insulin allergy was found more frequently in patients using acid insulin preparations and by frequent changes of the type of preparation. It is recommended that in special categories of diabetic patients--such as growing up, pregnant women, with complications of insulin treatment--only neutral, swine and purified insulin preparation should be used.
在索非亚内分泌、老年医学和老年病学科学研究所，过去3年中有1723名糖尿病患者接受胰岛素治疗。其中150人被怀疑对胰岛素过敏。通过皮内试验测定患者对各种胰岛素制剂的敏感性。发现29名患者（1.68%）存在胰岛素过敏。使用酸性胰岛素制剂的患者以及频繁更换制剂类型的患者中胰岛素过敏更为常见。建议在特殊类型的糖尿病患者中，如青少年、孕妇、有胰岛素治疗并发症的患者，仅使用中性、猪源性和纯化胰岛素制剂。
