Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka, Japan.
Faculty of Nursing, Osaka Medical College, Osaka, Japan.
Geriatr Gerontol Int. 2019 Feb;19(2):130-134. doi: 10.1111/ggi.13565. Epub 2018 Nov 21.
Sleep disturbances in patients with Alzheimer's disease have not been systematically evaluated, because sleep monitoring has proved difficult. Our goal was to quantitatively characterize sleep disturbances in patients with Alzheimer's disease.
The present study was a cross-sectional descriptive study, carried out in dementia care units in Japan. Participants were 63 patients with Alzheimer's disease (mean age 77.6 ± 8.0 years) with severe behavioral and psychological symptoms of dementia. A non-wearable actigraphy device placed under patient mattresses was used to measure sleep parameters: sleep time, time in bed, number of wakings and number of times they left the bed. Cut-off points for sleep parameters were based on the interquartile range of the data.
Median nocturnal sleep time was 6.2 h (interquartile range 2.7 h). Median frequency of waking was eight times (5)/night. Median frequency of leaving the bed was five times (6), with a maximum of 31/night. We identified three types of sleep disturbance: frequent bed leaving, short sleep time and excessive sleep time. Multiple linear regression showed that duration of dementia was a significant predictor of frequent bed leaving at night (P = 0.042).
Frequent bed leaving at night reflects severe sleep deprivation in patients with mild-to-severe Alzheimer's disease. Safety measures are required to prevent accidents related to sleep disturbances, regardless of dementia severity. Geriatr Gerontol Int 2019; 19: 130-134.
由于睡眠监测较为困难，因此阿尔茨海默病患者的睡眠障碍尚未得到系统评估。我们的目标是定量描述阿尔茨海默病患者的睡眠障碍。
本研究为横断面描述性研究，在日本的痴呆护理病房进行。参与者为 63 名患有阿尔茨海默病的患者（平均年龄 77.6±8.0 岁），这些患者均伴有严重的行为和心理症状性痴呆。使用放置在患者床垫下的非穿戴式活动记录仪来测量睡眠参数：睡眠时间、卧床时间、觉醒次数和离床次数。睡眠参数的截止值基于数据的四分位距。
夜间睡眠的中位数时间为 6.2 小时（四分位距为 2.7 小时）。觉醒的中位数频率为 8 次/晚。离床的中位数频率为 5 次/晚，最多为 31 次/晚。我们确定了三种类型的睡眠障碍：频繁离床、睡眠时间短和睡眠时间过长。多元线性回归显示痴呆持续时间是夜间频繁离床的显著预测因子（P=0.042）。
夜间频繁离床反映了轻度至重度阿尔茨海默病患者严重的睡眠剥夺。无论痴呆严重程度如何，都需要采取安全措施来预防与睡眠障碍相关的事故。老年医学与老年健康国际杂志 2019；19：130-134。
